Colin R Jefcoate
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Explore the profile of Colin R Jefcoate including associated specialties, affiliations and a list of published articles.
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57
Citations
839
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Recent Articles
21.
Bushkofsky J, Maguire M, Larsen M, Fong Y, Jefcoate C
Arch Biochem Biophys
. 2016 Apr;
597:30-47.
PMID: 27036855
Cytochrome P450 1b1 (Cyp1b1) is expressed in endothelia, stellate cells and pre-adipocytes, but not hepatocytes. Deletion alters liver fatty acid metabolism and prevents obesity and hepatic steatosis. This suggests a...
22.
Larsen M, Bushkofsky J, Gorman T, Adhami V, Mukhtar H, Wang S, et al.
Arch Biochem Biophys
. 2015 Feb;
571:21-39.
PMID: 25703193
Cytochrome P450 1b1 (Cyp1b1) expression is absent in mouse hepatocytes, but present in liver endothelia and activated stellate cells. Increased expression during adipogenesis suggests a role of Cyp1b1 metabolism in...
23.
Li F, Jiang C, Larsen M, Bushkofsky J, Krausz K, Wang T, et al.
J Proteome Res
. 2014 Apr;
13(5):2679-87.
PMID: 24684199
Cytochrome P450 1B1 (CYP1B1) is involved in the metabolism of xenobiotic compounds and endogenous metabolites. Disruption of Cyp1b1 in mice results in suppression of high-fat diet (HFD)-induced obesity and an...
24.
Piccinato C, Rosa G, Njai A, Jefcoate C, Wiltbank M
PLoS One
. 2013 Sep;
8(9):e73552.
PMID: 24069207
Female sex steroid hormones, estradiol-17β (E2-17β) and progesterone (P4) regulate reproductive function and gene expression in a broad range of tissues. Given the central role of the liver in regulating...
25.
Zhao Y, Wang S, Sorenson C, Teixeira L, Dubielzig R, Peters D, et al.
Mol Cell Biol
. 2013 Aug;
33(21):4225-40.
PMID: 23979599
Mutation in CYP1B1 has been reported for patients with congenital glaucoma. However, the underlying mechanisms remain unknown. Here we show increased diurnal intraocular pressure (IOP) in Cyp1b1-deficient (Cyp1b1(-/-)) mice. Cyp1b1(-/-)...
26.
Palenski T, Sorenson C, Jefcoate C, Sheibani N
Lab Invest
. 2013 Apr;
93(6):646-62.
PMID: 23568032
Perivascular supporting cells, including pericytes and smooth muscle cells (PC/SMC), have an integral role during angiogenesis and control vascular remodeling, maturation, and stabilization of neoteric vessels. We recently showed that...
27.
Zheng W, Tong T, Lee J, Liu X, Marcus C, Jefcoate C
Arch Biochem Biophys
. 2013 Feb;
532(1):1-14.
PMID: 23376040
Cytochrome P4501B1 (Cyp1b1) is expressed specifically in certain neural crest (NC) cells during embryogenesis. Mesenchymal progenitor cells that develop from NC cells are modeled here by mouse C3H10T1/2 and 3T3-L1...
28.
Njai A, Larsen M, Bushkofsky J, Czuprynski C, Jefcoate C
Mol Pharmacol
. 2011 Jan;
79(4):724-34.
PMID: 21252291
Bone marrow (BM) hematopoietic cells are selectively sensitive to polycyclic aromatic hydrocarbons (PAH) in vivo. 7,12-Dimethylbenz(a)anthracene (DMBA), but not benzo(a)pyrene (BP), depletes BM hematopoietic cells in C57BL/6 mice. This difference...
29.
Jefcoate C, Lee J, Cherradi N, Takemori H, Duan H
Mol Cell Endocrinol
. 2010 Dec;
336(1-2):53-62.
PMID: 21147196
The steroidogenic acute regulatory (StAR) protein is generated in rodents from 1.6 kb and 3.5 kb mRNA formed by alternative polyadenylation. The zinc finger protein, TIS11B (also Znf36L1), is elevated...
30.
Tang Y, Scheef E, Gurel Z, Sorenson C, Jefcoate C, Sheibani N
Am J Physiol Cell Physiol
. 2009 Dec;
298(3):C665-78.
PMID: 20032512
We have recently shown that deletion of constitutively expressed CYP1B1 is associated with attenuation of retinal endothelial cell (EC) capillary morphogenesis (CM) in vitro and angiogenesis in vivo. This was...