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Colin R Jefcoate

Explore the profile of Colin R Jefcoate including associated specialties, affiliations and a list of published articles. Areas
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Articles 57
Citations 839
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Recent Articles
11.
Veith A, Bou Aram B, Jiang W, Wang L, Zhou G, Jefcoate C, et al.
Toxicol Sci . 2018 Jun; 165(2):462-474. PMID: 29939353
Supplemental oxygen is a life-saving intervention administered to individuals suffering from respiratory distress, including adults with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Despite the clinical benefit,...
12.
Huang Y, Karasov W, Patnode K, Jefcoate C
Environ Toxicol Chem . 2018 Jun; 18(10):2123-2130. PMID: 29857620
We measured concentrations of polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) in northern leopard frogs collected from the Green Bay ecosystem and explored the catalytic activity of...
13.
Jefcoate C, Lee J
J Mol Endocrinol . 2018 Apr; 60(4):R213-R235. PMID: 29691317
Cholesterol is an important regulator of cell signaling, both through direct impacts on cell membranes and through oxy-metabolites that activate specific receptors (steroids, hydroxy-cholesterols, bile acids). Cholesterol moves slowly through...
14.
Seok S, Ma Z, Feltenberger J, Chen H, Chen H, Scarlett C, et al.
J Biol Chem . 2017 Dec; 293(6):1994-2005. PMID: 29279331
Cellular metabolites act as important signaling cues, but are subject to complex unknown chemistry. Kynurenine is a tryptophan metabolite that plays a crucial role in cancer and the immune system....
15.
Maguire M, Larsen M, Foong Y, Tanumihardjo S, Jefcoate C
Mol Cell Endocrinol . 2017 Jun; 454:50-68. PMID: 28583802
Conclusions: The LF12 diet delivered low post-natal iron and attenuated Hepc. Hepc decreases in Cyp1b1-/- and GVAD mice resulted in stellate activation and lipogenesis suppression. Endothelial BMP6, a Hepc stimulant,...
16.
Maguire M, Bushkofsky J, Larsen M, Foong Y, Tanumihardjo S, Jefcoate C
J Nutr Biochem . 2017 Jun; 47:63-74. PMID: 28570941
For mice, a maternal vitamin A (VA)-deficient diet initiated from midgestation (GVAD) produces serum retinol deficiency in mature offspring. We hypothesize that the effects of GVAD arise from preweaning developmental...
17.
Larsen M, Njai A, Alexander D, Rondelli C, Forsberg E, Czuprynski C, et al.
Pharmacol Res Perspect . 2017 Jan; 4(4):e00245. PMID: 28116098
Bone marrow (BM) hematopoietic stem cells differentiate to common lymphoid progenitors (CLP) that emigrate to the thymus to form T cells or differentiate into immature B cells that then migrate...
18.
Rondelli C, Larsen M, Njai A, Czuprynski C, Jefcoate C
Stem Cells Int . 2016 Nov; 2016:1753491. PMID: 27891153
7,12-Dimethylbenz(a)anthracene (DMBA) rapidly suppresses hematopoietic progenitors, measured as colony forming units (CFU), in mouse bone marrow (BM) leading to mature cell losses as replenishment fails. These losses are mediated by...
19.
Kim S, Trinh A, Larsen M, Mastrocola A, Jefcoate C, Bushel P, et al.
Nucleic Acids Res . 2016 Jul; 44(20):9667-9680. PMID: 27431323
cAMP response element binding protein (CREB) is a key regulator of glucose metabolism and synaptic plasticity that is canonically regulated through recruitment of transcriptional coactivators. Here we show that phosphorylation...
20.
Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate C, et al.
Biochem Biophys Res Commun . 2016 May; 476(4):346-351. PMID: 27235555
Supplemental oxygen, which is routinely administered to preterm infants with pulmonary insufficiency, contributes to bronchopulmonary dysplasia (BPD) in these infants. Hyperoxia also contributes to the development of acute lung injury...