Colin Levy
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Explore the profile of Colin Levy including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Ortmayer M, Fisher K, Basran J, Wolde-Michael E, Heyes D, Levy C, et al.
ACS Catal
. 2020 Jun;
10(4):2735-2746.
PMID: 32550044
Nature employs a limited number of genetically encoded axial ligands to control diverse heme enzyme activities. Deciphering the functional significance of these ligands requires a quantitative understanding of how their...
12.
Tunnicliffe R, Hu W, Wu M, Levy C, Mould A, Mckenzie E, et al.
mBio
. 2019 Oct;
10(5).
PMID: 31641093
Serine-arginine (SR) protein kinase 1 (SRPK1) catalyzes the phosphorylation of SR proteins, which are a conserved family of splicing factors that contain a domain rich in arginine and serine repeats....
13.
Burke A, Lovelock S, Frese A, Crawshaw R, Ortmayer M, Dunstan M, et al.
Nature
. 2019 May;
570(7760):219-223.
PMID: 31132786
The combination of computational design and laboratory evolution is a powerful and potentially versatile strategy for the development of enzymes with new functions. However, the limited functionality presented by the...
14.
Iorgu A, Baxter N, Cliff M, Levy C, Waltho J, Hay S, et al.
ACS Catal
. 2019 May;
8(12):11589-11599.
PMID: 31119061
Many enzymes that catalyze hydride transfer reactions work via a mechanism dominated by quantum mechanical tunneling. The involvement of fast vibrational modes of the reactive complex is often inferred in...
15.
Tunnicliffe R, Levy C, Nivia H, Sandri-Goldin R, Golovanov A
Nucleic Acids Res
. 2018 Nov;
47(4):1987-2001.
PMID: 30462297
Kaposi's sarcoma-associated herpesvirus (KSHV) transcribes a long noncoding polyadenylated nuclear (PAN) RNA, which promotes the latent to lytic transition by repressing host genes involved in antiviral responses as well as...
16.
Bennett M, Thompson M, Shepherd S, Dunstan M, Herbert A, Smith D, et al.
Angew Chem Int Ed Engl
. 2018 May;
57(33):10600-10604.
PMID: 29791083
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse family of plant secondary metabolites, which have been exploited to develop analgesics, antibiotics, antitumor agents, and other therapeutic agents. Biosynthesis of BIAs proceeds...
17.
Shepherd S, Karthikeyan C, Latham J, Struck A, Thompson M, Menon B, et al.
Chem Sci
. 2018 Mar;
6(6):3454-3460.
PMID: 29511510
Flavin-dependent halogenases are potentially valuable biocatalysts for the regioselective halogenation of aromatic compounds. These enzymes, utilising benign inorganic halides, offer potential advantages over traditional non-enzymatic halogenation chemistry that often lacks...
18.
Gahloth D, Levy C, Walker L, Wunderley L, Mould A, Taylor S, et al.
Structure
. 2017 Jun;
25(7):1011-1024.e4.
PMID: 28602823
SARA and endofin are endosomal adaptor proteins that drive Smad phosphorylation by ligand-activated transforming growth factor β/bone morphogenetic protein (TGFβ/BMP) receptors. We show in this study that SARA and endofin...
19.
Tunnicliffe R, Lockhart-Cairns M, Levy C, Mould A, Jowitt T, Sito H, et al.
Nucleic Acids Res
. 2017 May;
45(13):8064-8078.
PMID: 28505309
The transcription factor ICP4 from herpes simplex virus has a central role in regulating the gene expression cascade which controls viral infection. Here we present the crystal structure of the...
20.
Jones S, Ahmet J, Ayton K, Ball M, Cockerill M, Fairweather E, et al.
J Med Chem
. 2016 Dec;
59(24):11120-11137.
PMID: 28002956
A collaborative high throughput screen of 1.35 million compounds against mutant (R132H) isocitrate dehydrogenase IDH1 led to the identification of a novel series of inhibitors. Elucidation of the bound ligand...