Colin J Suckling
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Explore the profile of Colin J Suckling including associated specialties, affiliations and a list of published articles.
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77
Citations
674
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Recent Articles
1.
Perieteanu M, Garzon T, McGee L, Khalaf A, Suckling C, Beveridge R, et al.
RSC Med Chem
. 2024 Nov;
PMID: 39493220
There were an estimated 249 million cases of malaria globally in 2022, causing approximately 608 000 deaths. Most of these are attributed to infection by . Strathclyde minor groove binders...
2.
Riley C, Ammar U, Alsfouk A, Anthony N, Baiget J, Berretta G, et al.
Molecules
. 2024 Aug;
29(15).
PMID: 39124921
The inhibitory-kappaB kinases (IKKs) IKKα and IKKβ play central roles in regulating the non-canonical and canonical NF-κB signalling pathways. Whilst the proteins that transduce the signals of each pathway have...
3.
McGee L, Carpinteyro Sanchez A, Perieteanu M, Eskandari K, Bian Y, Mackie L, et al.
J Antimicrob Chemother
. 2024 Jul;
79(9):2251-2258.
PMID: 38980760
Background: Acanthamoeba spp. is the causative agent of Acanthamoeba keratitis and granulomatous amoebic encephalitis. Strathclyde minor groove binders (S-MGBs) are a promising new class of anti-infective agent that have been...
4.
Suckling C
RSC Med Chem
. 2024 Feb;
15(2):472-484.
PMID: 38389887
The challenges of bringing new medicines to patients have been extensively discussed and debated, including consideration of the contribution that academic laboratories can make. At the University of Strathclyde, drug...
5.
Rodriguez-Fernandez P, Botella L, Cavet J, Dominguez J, Gutierrez M, Suckling C, et al.
ACS Infect Dis
. 2023 Dec;
10(1):170-183.
PMID: 38085851
Treatment of and infections requires multiple drugs for long time periods. Mycobacterium protein-tyrosine-phosphatase B (MptpB) is a key virulence factor that subverts host antimicrobial activity to promote intracellular survival. Inhibition...
6.
Harnett M, Lumb F, Crowe J, Doonan J, Buitrago G, Brown S, et al.
Front Immunol
. 2023 Dec;
14:1285069.
PMID: 38077318
Mice develop pathology in the lungs as they age and this may be accelerated by a high calorie diet (HCD). ES-62 is a protein secreted by the parasitic worm that...
7.
Tentellino C, Tipping W, McGee L, Bain L, Wetherill C, Laing S, et al.
RSC Chem Biol
. 2022 Dec;
3(12):1403-1415.
PMID: 36544571
Quantitative drug imaging in live cells is a major challenge in drug discovery and development. Many drug screening techniques are performed in solution, and therefore do not consider the impact...
8.
Hind C, Clifford M, Woolley C, Harmer J, McGee L, Tyson-Hirst I, et al.
ACS Infect Dis
. 2022 Nov;
8(12):2552-2563.
PMID: 36444998
MGB-BP-3 is a potential first-in-class antibiotic, a Strathclyde Minor Groove Binder (S-MGB), that has successfully completed Phase IIa clinical trials for the treatment of associated disease. Its precise mechanism of...
9.
Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification
Perieteanu M, McGee L, Shaw C, Macmillan D, Khalaf A, Gillingwater K, et al.
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36233213
The neglected tropical disease leishmaniasis, caused by Leishmania spp., is becoming more problematic due to the emergence of drug-resistant strains. Therefore, new drugs to treat leishmaniasis, with novel mechanisms of...
10.
Harnett M, Doonan J, Lumb F, Crowe J, Damink R, Buitrago G, et al.
Front Immunol
. 2022 Sep;
13:953053.
PMID: 36105811
Despite significant increases in human lifespan over the last century, adoption of high calorie diets (HCD) has driven global increases in type-2 diabetes, obesity and cardiovascular disease, disorders precluding corresponding...