Colin J Suckling
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Explore the profile of Colin J Suckling including associated specialties, affiliations and a list of published articles.
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77
Citations
674
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Recent Articles
11.
Suckling C, Hunter I, Scott F
Future Drug Discov
. 2022 May;
4(1):FDD73.
PMID: 35600289
The standard drug discovery paradigm of single molecule - single biological target - single biological effect is perhaps particularly unsuitable for anti-infective drug discovery. This is due to the rapid...
12.
Kieswetter N, Ozturk M, Hlaka L, Chia J, Nichol R, Cross J, et al.
J Antimicrob Chemother
. 2022 Jan;
77(4):1061-1071.
PMID: 35084027
Background: Previously, we evaluated the intracellular mycobactericidal activity of the minor groove binder, S-MGB-364 against the clinical Mycobacterium tuberculosis (Mtb) strain HN878 in macrophages. Objectives: To assess the mycobactericidal activity...
13.
Brooke D, McGee L, Giordani F, Cross J, Khalaf A, Irving C, et al.
RSC Med Chem
. 2022 Jan;
12(12):2071.
PMID: 35024615
[This corrects the article DOI: 10.1039/D1MD00110H.].
14.
Giordani F, Khalaf A, Gillingwater K, Munday J, de Koning H, Suckling C, et al.
J Med Chem
. 2021 Dec;
64(24):18236.
PMID: 34854304
No abstract available.
15.
Corbet M, Pineda M, Yang K, Tarafdar A, McGrath S, Nakagawa R, et al.
PLoS Pathog
. 2021 Nov;
17(11):e1010069.
PMID: 34748611
ES-62 is the major secreted protein of the parasitic filarial nematode, Acanthocheilonema viteae. The molecule exists as a large tetramer (MW, ~240kD), which possesses immunomodulatory properties by virtue of multiple...
16.
Brooke D, McGee L, Giordani F, Cross J, Khalaf A, Irving C, et al.
RSC Med Chem
. 2021 Aug;
12(8):1391-1401.
PMID: 34447938
This paper describes the design and synthesis of Strathclyde minor groove binders (S-MGBs) that have been truncated by the removal of a pyrrole ring in order to mimic the structure...
17.
Jones K, Beaumont D, Bernard S, Bit R, Campbell S, Chung C, et al.
J Med Chem
. 2021 Aug;
64(16):12200-12227.
PMID: 34387088
The functions of the bromodomain and extra terminal (BET) family of proteins have been implicated in a wide range of diseases, particularly in the oncology and immuno-inflammatory areas, and several...
18.
Nichol R, Khalaf A, Sooda K, Hussain O, Griffiths H, Phillips R, et al.
Medchemcomm
. 2020 Sep;
10(9):1620-1634.
PMID: 32952999
Traditional cytotoxic agents which act through a DNA-alkylating mechanism are relatively non-specific, resulting in a small therapeutic window and thus limiting their effectiveness. In this study, we evaluate a panel...
19.
Borthwick J, Alemparte C, Wall I, Whitehurst B, Argyrou A, Burley G, et al.
J Med Chem
. 2020 Jan;
63(5):2557-2576.
PMID: 31922409
Decaprenylphosphoryl-β-d-ribose 2'-epimerase (DprE1) is an essential enzyme in and has recently been studied as a potential drug target, with inhibitors progressing to clinical studies. Here we describe the identification of...
20.
Lumb F, Crowe J, Doonan J, Suckling C, Selman C, Harnett M, et al.
Mol Biochem Parasitol
. 2019 Oct;
234:111232.
PMID: 31634505
One of the most rapidly increasing human public health problems is obesity, whose sequelae like type-2 diabetes, represent continuously worsening, life-long conditions. Over the last 15 years, data have begun...