Colin Adrain
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Explore the profile of Colin Adrain including associated specialties, affiliations and a list of published articles.
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42
Citations
1176
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Recent Articles
1.
Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
Chatterjee S, Naeli P, Onar O, Simms N, Garzia A, Hackett A, et al.
Nucleic Acids Res
. 2024 Oct;
52(20):12534-12548.
PMID: 39351862
Ribosome quality control (RQC) resolves collided ribosomes, thus preventing their cytotoxic effects. The chemotherapeutic agent 5-Fluorouracil (5FU) is best known for its misincorporation into DNA and inhibition of thymidylate synthase....
2.
Adrain C, Badenes M
FEBS J
. 2024 Apr;
291(10):2094-2097.
PMID: 38680125
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a transmembrane protein that, when cleaved by metalloproteases through a process called ectodomain shedding, binds to the EGF receptor (EGFR), activating downstream...
3.
Knopf J, Steigleder S, Korn F, Kuhnle N, Badenes M, Tauber M, et al.
Nat Commun
. 2024 Mar;
15(1):1528.
PMID: 38453906
The toll-like receptor 4 (TLR4) is a central regulator of innate immunity that primarily recognizes bacterial lipopolysaccharide cell wall constituents to trigger cytokine secretion. We identify the intramembrane protease RHBDL4...
4.
Blasius K, Ludwig L, Knapp S, Flasshove C, Sonnabend F, Keller D, et al.
Cell Mol Life Sci
. 2024 Feb;
81(1):102.
PMID: 38409522
The protease ADAM17 plays an important role in inflammation and cancer and is regulated by iRhom2. Mutations in the cytosolic N-terminus of human iRhom2 cause tylosis with oesophageal cancer (TOC)....
5.
Gaspar C, Gomes T, Martins J, Melo M, Adrain C, Cordeiro T, et al.
iScience
. 2023 Nov;
26(12):108309.
PMID: 38025784
Rhodopsin-1 (Rh1), the main photosensitive protein of , is a seven-transmembrane domain protein, which is inserted co-translationally in the endoplasmic reticulum (ER) membrane. Biogenesis of Rh1 occurs in the ER,...
6.
Amin A, Badenes M, Tushaus J, de Carvalho E, Burbridge E, Faisca P, et al.
Mol Metab
. 2023 Apr;
73:101731.
PMID: 37121509
Objective: The metalloprotease ADAM17 (also called TACE) plays fundamental roles in homeostasis by shedding key signaling molecules from the cell surface. Although its importance for the immune system and epithelial...
7.
Badenes M, Burbridge E, Oikonomidi I, Amin A, de Carvalho E, Kosack L, et al.
Life Sci Alliance
. 2023 Jan;
6(4).
PMID: 36720499
The metalloprotease ADAM17 is a sheddase of key molecules, including TNF and epidermal growth factor receptor ligands. ADAM17 exists within an assemblage, the "sheddase complex," containing a rhomboid pseudoprotease (iRhom1...
8.
Burbridge E, Adrain C
FEBS J
. 2022 Nov;
289(22):6822-6831.
PMID: 36377590
The major criterion that distinguishes eukaryotes from prokaryotes is the presence of organelles in the former. Organelles provide a compartment in which biochemical processes are corralled within bespoke biophysical conditions...
9.
Li X, Straub J, Medeiros T, Mehra C, den Brave F, Peker E, et al.
Science
. 2022 Jan;
375(6577):eabi4343.
PMID: 35025629
The outer mitochondrial membrane (OMM) is essential for cellular homeostasis. Yet little is known of the mechanisms that remodel it during natural stresses. We found that large “SPOTs” (structures positive...
10.
EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel
Gaspar C, Vieira L, Santos C, Christianson J, Jakubec D, Strisovsky K, et al.
EMBO Rep
. 2021 Dec;
23(1):e53210.
PMID: 34918864
The ER membrane protein complex (EMC) is required for the biogenesis of a subset of tail anchored (TA) and polytopic membrane proteins, including Rhodopsin-1 (Rh1) and the TRP channel. To...