Matthew Freeman
Overview
Explore the profile of Matthew Freeman including associated specialties, affiliations and a list of published articles.
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Articles
112
Citations
3215
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Recent Articles
1.
Siletti C, Freeman M, Dang H, Tu Z, Stevenson D, Amador-Noguez D, et al.
Infect Immun
. 2024 Nov;
92(12):e0044024.
PMID: 39560402
C-di-AMP homeostasis is critical for bacterial stress response, cell wall integrity, and virulence. Except for osmotic stress response, the molecular mechanisms underlying other processes are not well defined. A mutant...
2.
Eta-secretase-like processing of the amyloid precursor protein (APP) by the rhomboid protease RHBDL4
Penalva Y, Paschkowsky S, Recinto S, Duchesne A, Hammond T, Spiegler P, et al.
J Biol Chem
. 2024 Jul;
300(8):107541.
PMID: 38992438
The amyloid precursor protein (APP) is a key protein in Alzheimer's disease synthesized in the endoplasmic reticulum (ER) and translocated to the plasma membrane where it undergoes proteolytic cleavages by...
3.
Shioda K, Lamar F, Mucache H, Marri A, Chew J, Levy K, et al.
medRxiv
. 2024 May;
PMID: 38798325
Background: Chickens are an important source of animal protein, nutrition, and income in many low- and middle-income countries (LMICs). They are also a major reservoir of enteropathogens that contribute to...
4.
Lu F, Zhao H, Dai Y, Wang Y, Lee C, Freeman M
Mol Cell
. 2024 May;
84(11):2152-2165.e5.
PMID: 38781971
A disintegrin and metalloprotease 17 (ADAM17) is a membrane-tethered protease that triggers multiple signaling pathways. It releases active forms of the primary inflammatory cytokine tumor necrosis factor (TNF) and cancer-implicated...
5.
Siletti C, Freeman M, Tu Z, Stevenson D, Amador-Noguez D, Sauer J, et al.
bioRxiv
. 2024 Jan;
PMID: 38293011
Importance: C-di-AMP regulates both bacterial pathogenesis and interactions with the host. Although c-di-AMP is essential in many bacteria, its accumulation also attenuates the virulence of many bacterial pathogens. Therefore, disrupting...
6.
Dulloo I, Tellier M, Levet C, Chikh A, Zhang B, Blaydon D, et al.
Mol Cell
. 2024 Jan;
84(2):277-292.e9.
PMID: 38183983
iRhoms are pseudoprotease members of the rhomboid-like superfamily and are cardinal regulators of inflammatory and growth factor signaling; they function primarily by recognizing transmembrane domains of their clients. Here, we...
7.
Freeman M, Khela M, Mormino S, Creager A, Lyden E, Siebler J
J Surg Educ
. 2023 Oct;
81(1):145-150.
PMID: 37880034
Objective: We sought to create a novel method of teaching orthopedic trainees to efficiently obtain intraoperative radiographs using nonfluoroscopic digital cameras. Specifically, teaching them to make minor, uniplanar, adjustments while...
8.
Rocha J, Jayaram S, Stevens T, Muschalik N, Shah R, Emran S, et al.
PLoS Biol
. 2023 Aug;
21(8):e3002222.
PMID: 37552676
The human genome encodes approximately 20,000 proteins, many still uncharacterised. It has become clear that scientific research tends to focus on well-studied proteins, leading to a concern that poorly understood...
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