Clement Opoku-Temeng
Overview
Explore the profile of Clement Opoku-Temeng including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
636
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Recent Articles
1.
Opoku-Temeng C, Freedman B, Porter A, Kobayashi S, Chen L, Kreiswirth B, et al.
Microbiol Spectr
. 2022 Oct;
10(6):e0151722.
PMID: 36264264
Carbapenem-resistant Klebsiella pneumoniae isolates classified as multilocus sequence type 258 (ST258) are a problem in health care settings in many countries globally. ST258 isolates are resistant to multiple classes of...
2.
Innate Host Defense against Klebsiella pneumoniae and the Outlook for Development of Immunotherapies
Opoku-Temeng C, Malachowa N, Kobayashi S, DeLeo F
J Innate Immun
. 2021 Oct;
14(3):167-181.
PMID: 34628410
Klebsiella pneumoniae (K. pneumoniae) is a Gram-negative commensal bacterium and opportunistic pathogen. In healthy individuals, the innate immune system is adept at protecting against K. pneumoniae infection. Notably, the serum...
3.
Opoku-Temeng C, Kobayashi S, DeLeo F
Comput Struct Biotechnol J
. 2019 Nov;
17:1360-1366.
PMID: 31762959
Carbapenem-resistant (CR) has emerged as an urgent public health threat in many industrialized countries worldwide, including the United States. Infections caused by CR are difficult to treat because these organisms...
4.
Inhibitors of Intracellular Gram-Positive Bacterial Growth Synthesized via Povarov-Doebner Reactions
Dayal N, Opoku-Temeng C, Mohammad H, Abutaleb N, Hernandez D, Onyedibe K, et al.
ACS Infect Dis
. 2019 Sep;
5(11):1820-1830.
PMID: 31512848
can survive both inside and outside of phagocytic and nonphagocytic host cells. Once in the intracellular milieu, most antibiotics have reduced ability to kill , thus resulting in relapse of...
5.
Opoku-Temeng C, Onyedibe K, Aryal U, Sintim H
J Proteomics
. 2019 Apr;
202:103368.
PMID: 31028946
Halogenated 4-hydroxybenzylidene indolinones have been shown to re-sensitize methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE) to methicillin and vancomycin respectively. The mechanism of antibiotic re-sensitization was however not...
6.
Naclerio G, Karanja C, Opoku-Temeng C, Sintim H
ChemMedChem
. 2019 Apr;
14(10):1000-1004.
PMID: 30939229
The rise of antibiotic resistance, especially in Staphylococcus aureus, and the increasing death rate due to multiresistant bacteria have been well documented. The need for new chemical entities and/or the...
7.
Naganna N, Opoku-Temeng C, Choi E, Larocque E, Chang E, Carter-Cooper B, et al.
EBioMedicine
. 2019 Jan;
40:231-239.
PMID: 30686755
Background: Acute myeloid leukemia (AML) remains one of the most lethal, rarely cured cancers, despite decades of active development of AML therapeutics. Currently, the 5-year survival of AML patients is...
8.
Zheng Y, Tsuji G, Opoku-Temeng C, Sintim H
Chem Sci
. 2018 Jul;
7(9):6238-6244.
PMID: 30034764
Various important cellular processes in bacteria are controlled by c-di-GMP, such as motility, biofilm formation and virulence factors production. C-di-GMP is synthesized from two molecules of GTP by diguanylate cyclases...
9.
Opoku-Temeng C, Naclerio G, Mohammad H, Dayal N, Abutaleb N, Seleem M, et al.
Eur J Med Chem
. 2018 Jun;
155:797-805.
PMID: 29957525
Various reports of multidrug-resistant bacteria that are immune to all available FDA-approved drugs demand the development of novel chemical scaffolds as antibiotics. From screening a chemical library, we identified compounds...
10.
Opoku-Temeng C, Dayal N, Sooreshjani M, Sintim H
Bioorg Chem
. 2018 Apr;
78:418-426.
PMID: 29698892
Histone modification, a post-translational modification of histones and involving various covalent tags, such as methyl, phosphate and acetate groups, affects gene expression and hence modulates various cellular events, including growth...