Clayton K Collings
Overview
Explore the profile of Clayton K Collings including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1131
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Recent Articles
1.
Patil A, Strom A, Paulo J, Collings C, Ruff K, Shinn M, et al.
Cell
. 2023 Oct;
186(22):4936-4955.e26.
PMID: 37788668
Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear protein content. The prevailing dogma is that IDRs engage in non-specific interactions because they are poorly constrained by evolutionary...
2.
Strine M, Cai W, Wei J, Alfajaro M, Filler R, Biering S, et al.
PLoS Biol
. 2023 Jun;
21(6):e3002097.
PMID: 37310920
Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding of Coronavirus Disease 2019 (COVID-19). We...
3.
Mas G, Man N, Nakata Y, Martinez-Caja C, Karl D, Beckedorff F, et al.
J Clin Invest
. 2023 May;
133(13).
PMID: 37200093
During emergency hematopoiesis, hematopoietic stem cells (HSCs) rapidly proliferate to produce myeloid and lymphoid effector cells, a response that is critical against infection or tissue injury. If unresolved, this process...
4.
Battistello E, Hixon K, Comstock D, Collings C, Chen X, Rodriguez Hernaez J, et al.
Mol Cell
. 2023 Mar;
83(8):1216-1236.e12.
PMID: 36944333
Highly coordinated changes in gene expression underlie T cell activation and exhaustion. However, the mechanisms by which such programs are regulated and how these may be targeted for therapeutic benefit...
5.
Wei J, Patil A, Collings C, Alfajaro M, Liang Y, Cai W, et al.
Nat Genet
. 2023 Mar;
55(3):471-483.
PMID: 36894709
Identification of host determinants of coronavirus infection informs mechanisms of viral pathogenesis and can provide new drug targets. Here we demonstrate that mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) chromatin remodeling complexes, specifically...
6.
Celen C, Chuang J, Shen S, Li L, Maggiore G, Jia Y, et al.
Cell Rep
. 2022 Nov;
41(5):111581.
PMID: 36323264
The dynamic regulation of β-cell abundance is poorly understood. Since chromatin remodeling plays critical roles in liver regeneration, these mechanisms could be generally important for regeneration in other tissues. Here,...
7.
Pierre R, Collings C, Guerra D, Widmer C, Bolonduro O, Mashtalir N, et al.
Nat Genet
. 2022 Jun;
54(6):861-873.
PMID: 35681054
Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling complexes establish and maintain chromatin accessibility and gene expression, and are frequently perturbed in cancer. Clear cell meningioma (CCM), an aggressive tumor of the...
8.
Zullow H, Sankar A, Ingram D, Guerra D, DAvino A, Collings C, et al.
Mol Cell
. 2022 Apr;
82(9):1737-1750.e8.
PMID: 35390276
Mammalian SWI/SNF (mSWI/SNF or BAF) ATP-dependent chromatin remodeling complexes play critical roles in governing genomic architecture and gene expression and are frequently perturbed in human cancers. Transcription factors (TFs), including...
9.
Xu G, Chhangawala S, Cocco E, Razavi P, Cai Y, Otto J, et al.
Nat Genet
. 2020 Jan;
52(2):198-207.
PMID: 31932695
Mutations in ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, are the most common alterations of the SWI/SNF complex in estrogen-receptor-positive (ER) breast cancer. We identify that ARID1A inactivating...
10.
Collings C, Little 3rd D, Schafer S, Anderson J
PLoS One
. 2019 Dec;
14(12):e0216515.
PMID: 31887110
The HIV genome is rich in A but not G or U and deficient in C. This nucleotide bias controls HIV phenotype by determining the highly unusual composition of all...