Claus V Hallwirth
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Explore the profile of Claus V Hallwirth including associated specialties, affiliations and a list of published articles.
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14
Citations
240
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Recent Articles
1.
Scott S, Grigson S, Hartkopf F, Hallwirth C, Alexander I, Bauer D, et al.
Data Brief
. 2022 May;
42:108161.
PMID: 35496474
Viral integration is a complex biological process, and it is useful to have a reference integration dataset with known properties to compare experimental data against, or for comparing with the...
2.
Scott S, Hallwirth C, Hartkopf F, Grigson S, Jain Y, Alexander I, et al.
J Mol Biol
. 2021 Dec;
434(11):167408.
PMID: 34929203
Detecting viral and vector integration events is a key step when investigating interactions between viral and host genomes. This is relevant in several fields, including virology, cancer research and gene...
3.
Cabanes-Creus M, Hallwirth C, Westhaus A, Ng B, Liao S, Zhu E, et al.
Sci Transl Med
. 2020 Sep;
12(560).
PMID: 32908003
Recent clinical successes in gene therapy applications have intensified interest in using adeno-associated viruses (AAVs) as vectors for therapeutic gene delivery. Although prototypical AAV2 shows robust in vitro transduction of...
4.
Cabanes-Creus M, Westhaus A, Navarro R, Baltazar G, Zhu E, Amaya A, et al.
Mol Ther Methods Clin Dev
. 2020 Jun;
17:1139-1154.
PMID: 32490035
Use of the prototypical adeno-associated virus type 2 (AAV2) capsid delivered unexpectedly modest efficacy in an early liver-targeted gene therapy trial for hemophilia B. This result is consistent with subsequent...
5.
Ginn S, Amaya A, Liao S, Zhu E, Cunningham S, Lee M, et al.
JHEP Rep
. 2020 Feb;
2(1):100065.
PMID: 32039406
Background & Aims: Genome editing technology has immense therapeutic potential and is likely to rapidly supplant contemporary gene addition approaches. Key advantages include the capacity to directly repair mutant loci...
6.
Cabanes-Creus M, Ginn S, Amaya A, Liao S, Westhaus A, Hallwirth C, et al.
Mol Ther Methods Clin Dev
. 2018 Dec;
12:71-84.
PMID: 30534580
Adeno-associated virus (AAV) vectors have become one of the most widely used gene transfer tools in human gene therapy. Considerable effort is currently being focused on AAV capsid engineering strategies...
7.
Logan G, Dane A, Hallwirth C, Smyth C, Wilkie E, Amaya A, et al.
Nat Genet
. 2017 Jun;
49(8):1267-1273.
PMID: 28628105
Vectors based on adeno-associated virus type 2 (AAV2) are powerful tools for gene transfer and genome editing applications. The level of interest in this system has recently surged in response...
8.
Kamboj A, Hallwirth C, Alexander I, McCowage G, Kramer B
BMC Bioinformatics
. 2017 Jun;
18(1):305.
PMID: 28623888
Background: The analysis of viral vector genomic integration sites is an important component in assessing the safety and efficiency of patient treatment using gene therapy. Alongside this clinical application, integration...
9.
Ginn S, Hallwirth C, Liao S, Teber E, Arthur J, Wu J, et al.
Mol Ther Nucleic Acids
. 2017 Mar;
6:1-14.
PMID: 28325276
In early gene therapy trials for SCID-X1, using γ-retroviral vectors, T cell leukemias developed in a subset of patients secondary to insertional proto-oncogene activation. In contrast, we have reported development...
10.
Smith R, Hallwirth C, Westerman M, Hetherington N, Tseng Y, Cecchini S, et al.
Sci Rep
. 2016 Jul;
6:28965.
PMID: 27377618
Germline endogenous viral elements (EVEs) genetically preserve viral nucleotide sequences useful to the study of viral evolution, gene mutation, and the phylogenetic relationships among host organisms. Here, we describe a...