Claudia Eulenberg-Gustavus
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Explore the profile of Claudia Eulenberg-Gustavus including associated specialties, affiliations and a list of published articles.
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8
Citations
111
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Recent Articles
1.
Kling L, Eulenberg-Gustavus C, Jerke U, Rousselle A, Eckardt K, Schreiber A, et al.
Front Immunol
. 2024 Oct;
15:1406967.
PMID: 39469705
During inflammation, human neutrophils engage β-integrins to migrate from the blood circulation to inflammatory sites with high cytokine but low oxygen concentrations. We tested the hypothesis that the inhibition of...
2.
Ebert M, Jerke U, Eulenberg-Gustavus C, Kling L, Jenne D, Kirchner M, et al.
J Clin Invest
. 2022 Sep;
132(23).
PMID: 36125911
BackgroundAntineutrophil cytoplasmic autoantibody-associated (ANCA-associated) vasculitidies (AAV) are life-threatening systemic autoimmune conditions. ANCAs directed against proteinase 3 (PR3) or myeloperoxidase (MPO) bind their cell surface-presented antigen, activate neutrophils, and cause vasculitis....
3.
Jerke U, Eulenberg-Gustavus C, Rousselle A, Nicklin P, Kreideweiss S, Grundl M, et al.
J Am Soc Nephrol
. 2022 Mar;
33(5):936-947.
PMID: 35292437
Background: The ANCA autoantigens proteinase 3 (PR3) and myeloperoxidase (MPO) are exclusively expressed by neutrophils and monocytes. ANCA-mediated activation of these cells is the key driver of the vascular injury...
4.
Arends C, Weiss M, Christen F, Eulenberg-Gustavus C, Rousselle A, Kettritz R, et al.
Haematologica
. 2019 Oct;
105(6):e264-e267.
PMID: 31582546
No abstract available.
5.
Seren S, Abouzaid M, Eulenberg-Gustavus C, Hirschfeld J, Soliman H, Jerke U, et al.
J Biol Chem
. 2018 Jun;
293(32):12415-12428.
PMID: 29925593
Membrane-bound proteinase 3 (PR3) is the main target antigen of anti-neutrophil cytoplasmic autoantibodies (ANCA) in granulomatosis with polyangiitis, a systemic small-vessel vasculitis. Binding of ANCA to PR3 triggers neutrophil activation...
6.
Choi M, Schreiber A, Eulenberg-Gustavus C, Scheidereit C, Kamps J, Kettritz R
J Am Soc Nephrol
. 2017 Jul;
28(11):3191-3204.
PMID: 28687535
ANCA-associated vasculitis (AAV) is a highly inflammatory condition in which ANCA-activated neutrophils interact with the endothelium, resulting in necrotizing vasculitis. We tested the hypothesis that endothelial NF-B mediates necrotizing crescentic...
7.
Eulenberg-Gustavus C, Bahring S, Maass P, Luft F, Kettritz R
J Exp Med
. 2017 Jun;
214(7):2089-2101.
PMID: 28559244
CD177 presents antigens in allo- and autoimmune diseases on the neutrophil surface. Individuals can be either CD177-deficient or harbor distinct CD177 and CD177 neutrophil subsets. We studied mechanisms controlling subset-restricted...
8.
Schreiber A, Eulenberg-Gustavus C, Bergmann A, Jerke U, Kettritz R
J Leukoc Biol
. 2016 Jul;
100(6):1443-1452.
PMID: 27365530
ANCA to either PR3 or MPO are found in patients with necrotizing vasculitis and glomerulonephritis. ANCA binding to their target antigens on neutrophils and subsequent neutrophil activation are pivotal disease...