Claude Philippe
Overview
Explore the profile of Claude Philippe including associated specialties, affiliations and a list of published articles.
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13
Citations
619
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Recent Articles
1.
Laisne M, Rodgers B, Benlamara S, Wicinski J, Nicolas A, Djerroudi L, et al.
Oncogene
. 2024 Mar;
43(18):1369-1385.
PMID: 38467851
Breast cancer is the most prevalent type of cancer in women worldwide. Within breast tumors, the basal-like subtype has the worst prognosis, prompting the need for new tools to understand,...
2.
Lanciano S, Philippe C, Sarkar A, Pratella D, Domrane C, Doucet A, et al.
Cell Genom
. 2024 Feb;
4(2):100498.
PMID: 38309261
Long interspersed element 1 (L1) retrotransposons are implicated in human disease and evolution. Their global activity is repressed by DNA methylation, but deciphering the regulation of individual copies has been...
3.
Philippe C, Cristofari G
Methods Mol Biol
. 2022 Nov;
2607:127-150.
PMID: 36449162
By silencing L1 retrotransposons, DNA methylation protects mammalian genomes from potent endogenous mutagens. However, some loci can escape this repressive mechanism and become active, particularly in carcinomas. Alterations of L1...
4.
Taylor D, Lowe R, Philippe C, Cheng K, Grant O, Zabet N, et al.
Nucleic Acids Res
. 2021 Dec;
50(6):e33.
PMID: 34908129
Despite a vast expansion in the availability of epigenomic data, our knowledge of the chromatin landscape at interspersed repeats remains highly limited by difficulties in mapping short-read sequencing data to...
5.
Sultana T, van Essen D, Siol O, Bailly-Bechet M, Philippe C, El Aabidine A, et al.
Mol Cell
. 2019 Apr;
74(3):555-570.e7.
PMID: 30956044
L1 retrotransposons are transposable elements and major contributors of genetic variation in humans. Where L1 integrates into the genome can directly impact human evolution and disease. Here, we experimentally induced...
6.
Philippe C, Vargas-Landin D, Doucet A, van Essen D, Vera-Otarola J, Kuciak M, et al.
Elife
. 2016 Mar;
5.
PMID: 27016617
LINE-1 (L1) retrotransposons represent approximately one sixth of the human genome, but only the human-specific L1HS-Ta subfamily acts as an endogenous mutagen in modern humans, reshaping both somatic and germline...
7.
Albrengues J, Bertero T, Grasset E, Bonan S, Maiel M, Bourget I, et al.
Nat Commun
. 2015 Dec;
6:10204.
PMID: 26667266
Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a proinvasive phenotype, which promotes extracellular matrix remodelling and collective invasion of...
8.
Mir A, Philippe C, Cristofari G
Nucleic Acids Res
. 2014 Oct;
43(Database issue):D43-7.
PMID: 25352549
Retrotransposons account for almost half of our genome. They are mobile genetics elements-also known as jumping genes--but only the L1HS subfamily of Long Interspersed Nuclear Elements (LINEs) has retained the...
9.
Simonet T, Zaragosi L, Philippe C, Lebrigand K, Schouteden C, Augereau A, et al.
Cell Res
. 2011 Mar;
21(7):1028-38.
PMID: 21423270
The study of the proteins that bind to telomeric DNA in mammals has provided a deep understanding of the mechanisms involved in chromosome-end protection. However, very little is known on...
10.
Terrand J, Bruban V, Zhou L, Gong W, El Asmar Z, May P, et al.
J Biol Chem
. 2008 Nov;
284(1):381-388.
PMID: 18990694
The low-density lipoprotein receptor-related protein LRP1 is a cell surface receptor with functions in diverse physiological pathways, including lipid metabolism. Here we show that LRP1-deficient fibroblasts accumulate high levels of...