Claude C Warzecha
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Explore the profile of Claude C Warzecha including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1207
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0
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Recent Articles
1.
Han X, Alameh M, Xu Y, Palanki R, El-Mayta R, Dwivedi G, et al.
Nat Biomed Eng
. 2024 Nov;
8(11):1412-1424.
PMID: 39578640
Ionizable lipids largely determine the biocompatibility of lipid nanoparticles (LNPs) and the efficacy for mRNA delivery. Rational design and combinatorial synthesis have led to the development of potent and biodegradable...
2.
Xue L, Zhao G, Gong N, Han X, Shepherd S, Xiong X, et al.
Nat Nanotechnol
. 2024 Oct;
20(1):132-143.
PMID: 39354147
Systemic delivery of messenger RNA (mRNA) for tissue-specific targeting using lipid nanoparticles (LNPs) holds great therapeutic potential. Nevertheless, how the structural characteristics of ionizable lipids (lipidoids) impact their capability to...
3.
Han X, Alameh M, Gong N, Xue L, Ghattas M, Bojja G, et al.
Nat Chem
. 2024 Jul;
16(10):1687-1697.
PMID: 38982196
Lipid nanoparticles (LNPs) are widely used for mRNA delivery, with cationic lipids greatly affecting biodistribution, cellular uptake, endosomal escape and transfection efficiency. However, the laborious synthesis of cationic lipids limits...
4.
Han X, Xu J, Xu Y, Alameh M, Xue L, Gong N, et al.
Nat Commun
. 2024 Feb;
15(1):1762.
PMID: 38409275
The ionizable lipidoid is a key component of lipid nanoparticles (LNPs). Degradable lipidoids containing extended alkyl branches have received tremendous attention, yet their optimization and investigation are underappreciated. Here, we...
5.
Wang L, Warzecha C, Kistner A, Chichester J, Bell P, Buza E, et al.
Mol Ther Methods Clin Dev
. 2022 Feb;
24:292-305.
PMID: 35211641
Ornithine transcarbamylase deficiency is a rare X-linked genetic urea cycle disorder leading to episodes of acute hyperammonemia, adverse cognitive and neurological effects, hospitalizations, and in some cases death. DTX301, a...
6.
Shepherd S, Warzecha C, Yadavali S, El-Mayta R, Alameh M, Wang L, et al.
Nano Lett
. 2021 Jun;
21(13):5671-5680.
PMID: 34189917
A major challenge to advance lipid nanoparticles (LNPs) for RNA therapeutics is the development of formulations that can be produced reliably across the various scales of drug development. Microfluidics can...
7.
Wang L, Breton C, Warzecha C, Bell P, Yan H, He Z, et al.
Mol Ther
. 2021 Feb;
29(6):2019-2029.
PMID: 33609733
Gene disruption via programmable, sequence-specific nucleases represents a promising gene therapy strategy in which the reduction of specific protein levels provides a therapeutic benefit. Proprotein convertase subtilisin/kexin type 9 (PCSK9),...
8.
Zhang R, El-Mayta R, Murdoch T, Warzecha C, Billingsley M, Shepherd S, et al.
Biomater Sci
. 2021 Jan;
9(4):1449-1463.
PMID: 33404020
Nucleic acids, such as messenger RNAs, antisense oligonucleotides, and short interfering RNAs, hold great promise for treating previously 'undruggable' diseases. However, there are numerous biological barriers that hinder nucleic acid...
9.
Yang Y, Park J, Bebee T, Warzecha C, Guo Y, Shang X, et al.
Mol Cell Biol
. 2016 Apr;
36(11):1704-19.
PMID: 27044866
The epithelial-to-mesenchymal transition (EMT) is an essential biological process during embryonic development that is also implicated in cancer metastasis. While the transcriptional regulation of EMT has been well studied, the...
10.
Bebee T, Park J, Sheridan K, Warzecha C, Cieply B, Rohacek A, et al.
Elife
. 2015 Sep;
4.
PMID: 26371508
Tissue- and cell-type-specific regulators of alternative splicing (AS) are essential components of posttranscriptional gene regulation, necessary for normal cellular function, patterning, and development. Mice with ablation of Epithelial splicing regulatory...