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Chu-Yi Yu

Explore the profile of Chu-Yi Yu including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 54
Citations 199
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
George W J Fleet
Atsushi Kato
Yue-Mei Jia
Yi-Xian Li
Yuna Shimadate
Robert J Nash
Jun-Zhe Wang
Xiang-Guo Hu
Shinpei Nakagawa
Maki Kise
Published In
Org Biomol Chem
J Org Chem
Eur J Med Chem
Org Lett
Acta Crystallogr Sect E Struct Rep Online
Affiliations
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Recent Articles
1.
C-2 fluorinated castanospermines as potent and specific α-glucosidase inhibitors: synthesis and structure-activity relationship study
Li Y, Zhang M, Shimadate Y, Kato A, Wang J, Jia Y, et al.
Org Biomol Chem . 2025 Feb; PMID: 39976182
C-2 Fluorinated castanospermines have been synthesized from a well-protected aldehyde precursor and evaluated as glycosidase inhibitors in comparison with castanospermine, 1--castanospermine and C-1 fluorinated castanospermines. While C-1 fluorinated castanospermines lose...
2.
Enantiomeric C-6 fluorinated swainsonine derivatives as highly selective and potent inhibitors of α-mannosidase and α-l-rhamnosidase: Design, synthesis and structure-activity relationship study
Gao F, Zhang M, Shimadate Y, Kato A, Li Y, Jia Y, et al.
Eur J Med Chem . 2024 Nov; 282:117031. PMID: 39556895
Six C-6 fluorinated d-swainsonine derivatives and their enantiomers have been designed based on initial docking calculations, and synthesized from enantiomeric ribose-derived aldehydes, respectively. Glycosidase inhibition assay of these derivatives with...
3.
Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity
Xu H, Zhang X, Wang X, Li B, Yu H, Quan Y, et al.
Immunity . 2024 Jun; 57(8):1796-1811.e8. PMID: 38908373
Prolonged activation of the type I interferon (IFN-I) pathway leads to autoimmune diseases such as systemic lupus erythematosus (SLE). Metabolic regulation of cytokine signaling is critical for cellular homeostasis. Through...
4.
Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives
Gao F, Wu Q, Zhang M, Shimadate Y, Qian G, Song Y, et al.
Eur J Med Chem . 2024 Jun; 275:116570. PMID: 38878517
Broussonetine S (9), its C-1' and C-10' stereoisomers, and their corresponding enantiomers have been synthesized from enantiomeric arabinose-derived cyclic nitrones, with cross metathesis (CM), epoxidation and Keck asymmetric allylation as...
5.
Design and synthesis of iso--DNJ and L-isoDALDP derivatives: pursuit of potent and selective inhibitors of α-glucosidase
Yang L, Zhang M, Shimadate Y, Kato A, Hou T, Li Y, et al.
Org Biomol Chem . 2023 Apr; 21(16):3453-3464. PMID: 37039337
A series of iso--DNJ and L-isoDALDP derivatives were synthesized from dithioacetal 16 with sequential and highly diastereoselective Ho and Henry reactions, and aziridinium intermediate-mediated ring rearrangement as key steps. Glycosidase...
6.
Design, synthesis and glycosidase inhibition of DAB derivatives with C-4 peptide and dipeptide branches
Zi D, Shimadate Y, Wang J, Kato A, Li Y, Jia Y, et al.
Org Biomol Chem . 2023 Mar; 21(13):2729-2741. PMID: 36916165
A series of DAB-peptide and DAB-dipeptide derivatives were synthesized from D-tartrate-derived nitrone 18. The DAB peptides 16 are derivatives of ,-3,4-dihydroxy-L-proline. Glycosidase inhibition assay found four of them to be...
7.
Nanomolar β-glucosidase and β-galactosidase inhibition by enantiomeric α-1-C-alkyl-1,4-dideoxy-1,4-imino-arabinitol derivatives
Zi D, Song Y, Lu T, Kise M, Kato A, Wang J, et al.
Eur J Med Chem . 2023 Jan; 247:115056. PMID: 36603505
A series of α-1-C-alkyl DAB (1,4-dideoxy-1,4-imino-d-arabinitol) and LAB (1,4-dideoxy-1,4-imino-l-arabinitol) derivatives with aryl substituents have been designed as analogues of broussonetine W (12), and assayed as glycosidase inhibitors. While the inhibition...
8.
C-6 fluorinated casuarines as highly potent and selective amyloglucosidase inhibitors: Synthesis and structure-activity relationship study
Li Y, Wang J, Shimadate Y, Kise M, Kato A, Jia Y, et al.
Eur J Med Chem . 2022 Nov; 244:114852. PMID: 36332547
A series of C-6 fluorinated casuarine derivatives have been synthesized via organocatalytic stereoselective α-fluorination of iminosugar-based aldehydes or direct nucleophilic fluorination of polyhydroxylated pyrrolizidines. Glycosidase assays against various glycosidases allowed...
9.
Introduction of -alkyl branches to L-iminosugars changes their active site binding orientation
Kato A, Nakagome I, Yoshimura K, Kanekiyo U, Kishida M, Shinzawa K, et al.
Org Biomol Chem . 2022 Jul; 20(36):7250-7260. PMID: 35838176
L--Deoxynojirimycin (L--DNJ) itself showed no affinity for human lysosomal acid α-glucosidase (GAA), whereas 5--methyl-L--DNJ showed a strong affinity for GAA, comparable to the glucose analog DNJ, with a value of...
10.
trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease
Wang J, Shimadate Y, Kise M, Kato A, Jia Y, Li Y, et al.
Eur J Med Chem . 2022 Jun; 238:114499. PMID: 35675756
Enantiomeric series of C-4 hydroxymethyl depleted DAB and LAB derivatives (trans, trans-2-C-aryl-3,4-dihydroxypyrrolidines), designed as β-glucosidase inhibitors by molecular docking calculations, have been synthesized in 2 steps from l- and d-tartaric...