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Christopher W Mount

Explore the profile of Christopher W Mount including associated specialties, affiliations and a list of published articles. Areas
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Articles 22
Citations 2544
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Recent Articles
11.
Majzner R, Ramakrishna S, Yeom K, Patel S, Chinnasamy H, Schultz L, et al.
Nature . 2022 Feb; 603(7903):934-941. PMID: 35130560
Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central nervous system. We have previously shown that the disialoganglioside GD2...
12.
Theruvath J, Sotillo E, Mount C, Graef C, Delaidelli A, Heitzeneder S, et al.
Nat Med . 2020 Apr; 26(5):712-719. PMID: 32341579
Atypical teratoid/rhabdoid tumors (ATRTs) typically arise in the central nervous system (CNS) of children under 3 years of age. Despite intensive multimodal therapy (surgery, chemotherapy and, if age permits, radiotherapy),...
13.
Mount C, Yalcin B, Cunliffe-Koehler K, Sundaresh S, Monje M
Elife . 2019 Oct; 8. PMID: 31625910
Neurons form bona fide synapses with oligodendrocyte precursor cells (OPCs), but the circuit context of these neuron to OPC synapses remains incompletely understood. Using monosynaptically-restricted rabies virus tracing of OPC...
14.
Majzner R, Theruvath J, Nellan A, Heitzeneder S, Cui Y, Mount C, et al.
Clin Cancer Res . 2019 Jan; 25(8):2560-2574. PMID: 30655315
Purpose: Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success...
15.
Mount C, Majzner R, Sundaresh S, Arnold E, Kadapakkam M, Haile S, et al.
Nat Med . 2018 Apr; 24(5):572-579. PMID: 29662203
Diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMGs) with mutated histone H3 K27M (H3-K27M) are aggressive and universally fatal pediatric brain cancers . Chimeric antigen receptor (CAR)-expressing...
16.
Mount C, Monje M
Neuron . 2017 Aug; 95(4):743-756. PMID: 28817797
Activity of the nervous system has long been recognized as a critical modulator of brain structure and function. Influences of experience on the cytoarchitecture and functional connectivity of neurons have...
17.
Venkatesh H, Johung T, Caretti V, Noll A, Tang Y, Nagaraja S, et al.
Cell . 2015 Apr; 161(4):803-16. PMID: 25913192
Active neurons exert a mitogenic effect on normal neural precursor and oligodendroglial precursor cells, the putative cellular origins of high-grade glioma (HGG). By using optogenetic control of cortical neuronal activity...
18.
Sellers D, Kim T, Mount C, Pun S, Horner P
Biomaterials . 2014 Jul; 35(31):8895-8902. PMID: 25064804
Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural...
19.
Gibson E, Purger D, Mount C, Goldstein A, Lin G, Wood L, et al.
Science . 2014 Apr; 344(6183):1252304. PMID: 24727982
Myelination of the central nervous system requires the generation of functionally mature oligodendrocytes from oligodendrocyte precursor cells (OPCs). Electrically active neurons may influence OPC function and selectively instruct myelination of...
20.
Chen C, Kim T, Wu W, Huang C, Wei H, Mount C, et al.
Biomaterials . 2013 Mar; 34(18):4501-9. PMID: 23498892
Polymeric micelles are promising carriers for anti-cancer agents due to their small size, ease of assembly, and versatility for functionalization. A current challenge in the use of polymeric micelles is...