Christopher V E Wright
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Explore the profile of Christopher V E Wright including associated specialties, affiliations and a list of published articles.
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92
Citations
7059
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Recent Articles
21.
Yang Y, Magnuson M, Stein R, Wright C
Development
. 2016 Dec;
144(2):248-257.
PMID: 27993987
The transcription factor Pdx1 is required for multiple aspects of pancreatic organogenesis. It remains unclear to what extent Pdx1 expression and function depend upon trans-activation through 5' conserved cis-regulatory regions...
22.
23.
Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A
Hoang C, Hale M, Azevedo-Pouly A, Elsasser H, Deering T, Willet S, et al.
Mol Cell Biol
. 2016 Oct;
36(24):3033-3047.
PMID: 27697859
Maintenance of cell type identity is crucial for health, yet little is known of the regulation that sustains the long-term stability of differentiated phenotypes. To investigate the roles that key...
24.
Bechard M, Bankaitis E, Hipkens S, Ustione A, Piston D, Yang Y, et al.
Genes Dev
. 2016 Sep;
30(16):1852-65.
PMID: 27585590
The current model for endocrine cell specification in the pancreas invokes high-level production of the transcription factor Neurogenin 3 (Neurog3) in Sox9(+) bipotent epithelial cells as the trigger for endocrine...
25.
Henley K, Stanescu D, Kropp P, Wright C, Won K, Stoffers D, et al.
Cell Rep
. 2016 Jun;
15(12):2637-2650.
PMID: 27292642
Pdx1 and Oc1 are co-expressed in multipotent pancreatic progenitors and regulate the pro-endocrine gene Neurog3. Their expression diverges in later organogenesis, with Oc1 absent from hormone+ cells and Pdx1 maintained...
26.
Aoki R, Shoshkes-Carmel M, Gao N, Shin S, May C, Golson M, et al.
Cell Mol Gastroenterol Hepatol
. 2016 Mar;
2(2):175-188.
PMID: 26949732
Background & Aims: Intestinal epithelial stem cells that express Lgr5 and/or Bmi1 continuously replicate and generate differentiated cells throughout life. Previously, Paneth cells were suggested to constitute an epithelium-intrinsic niche...
27.
Kodama S, Nakano Y, Hirata K, Furuyama K, Horiguchi M, Kuhara T, et al.
Sci Rep
. 2016 Feb;
6:21211.
PMID: 26887806
Endocrine and exocrine pancreas tissues are both derived from the posterior foregut endoderm, however, the interdependence of these two cell types during their formation is not well understood. In this...
28.
Pan F, Brissova M, Powers A, Pfaff S, Wright C
Development
. 2015 Nov;
142(21):3637-48.
PMID: 26534984
Homozygous Mnx1 mutation causes permanent neonatal diabetes in humans, but via unknown mechanisms. Our systematic and longitudinal analysis of Mnx1 function during murine pancreas organogenesis and into the adult uncovered...
29.
Bankaitis E, Bechard M, Wright C
Genes Dev
. 2015 Oct;
29(20):2203-16.
PMID: 26494792
In the mammalian pancreas, endocrine cells undergo lineage allocation upon emergence from a bipotent duct/endocrine progenitor pool, which resides in the "trunk epithelium." Major questions remain regarding how niche environments...
30.
Comer J, Pan F, Willet S, Haldipur P, Millen K, Wright C, et al.
Front Neural Circuits
. 2015 Aug;
9:36.
PMID: 26257608
Commissural neurons project across the midline at all levels of the central nervous system (CNS), providing bilateral communication critical for the coordination of motor activity and sensory perception. Midline crossing...