Christopher V E Wright
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Explore the profile of Christopher V E Wright including associated specialties, affiliations and a list of published articles.
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92
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7059
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Recent Articles
11.
Trogden K, Zhu X, Lee J, Wright C, Gu G, Kaverina I
Curr Biol
. 2019 Jul;
29(14):2339-2350.e5.
PMID: 31303487
The microtubule (MT) network is an essential regulator of insulin secretion from pancreatic β cells, which is central to blood-sugar homeostasis. We find that when glucose metabolism induces insulin secretion,...
12.
Spaeth J, Liu J, Peters D, Guo M, Osipovich A, Mohammadi F, et al.
Diabetes
. 2019 Jun;
68(9):1806-1818.
PMID: 31201281
Transcription factors positively and/or negatively impact gene expression by recruiting coregulatory factors, which interact through protein-protein binding. Here we demonstrate that mouse pancreas size and islet β-cell function are controlled...
13.
Wen H, Gao S, Wang Y, Ray M, Magnuson M, Wright C, et al.
Cell Mol Gastroenterol Hepatol
. 2019 May;
8(2):173-192.
PMID: 31125624
Background & Aims: Pancreatitis is a major cause of morbidity and mortality and is a risk factor for pancreatic tumorigenesis. Upon tissue damage, an inflammatory response, made up largely of...
14.
Wang X, Sterr M, Ansarullah , Burtscher I, Bottcher A, Beckenbauer J, et al.
Mol Metab
. 2019 Apr;
24:80-97.
PMID: 30930126
Objective: Hundreds of missense mutations in the coding region of PDX1 exist; however, if these mutations predispose to diabetes mellitus is unknown. Methods: In this study, we screened a large...
15.
Bankaitis E, Bechard M, Gu G, Magnuson M, Wright C
Development
. 2018 Aug;
145(18).
PMID: 30126902
During mouse pancreas organogenesis, endocrine cells are born from progenitors residing in an epithelial plexus niche. After a period in a lineage-primed state, progenitors become endocrine committed via upregulation of...
16.
Wang X, Sterr M, Burtscher I, Chen S, Hieronimus A, Machicao F, et al.
Mol Metab
. 2018 Feb;
9:57-68.
PMID: 29396371
Objective: Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous mutations can cause Maturity-Onset Diabetes of the Young 4...
17.
Zhang J, Weinrich J, Russ J, Comer J, Bommareddy P, DiCasoli R, et al.
Cell Rep
. 2017 Oct;
21(3):666-678.
PMID: 29045835
Spinal interneurons are critical modulators of motor circuit function. In the dorsal spinal cord, a set of interneurons called GABApre presynaptically inhibits proprioceptive sensory afferent terminals, thus negatively regulating sensory-motor...
18.
Larsen H, Martin-Coll L, Nielsen A, Wright C, Trusina A, Kim Y, et al.
Nat Commun
. 2017 Sep;
8(1):605.
PMID: 28928395
Spatiotemporal balancing of cellular proliferation and differentiation is crucial for postnatal tissue homoeostasis and organogenesis. During embryonic development, pancreatic progenitors simultaneously proliferate and differentiate into the endocrine, ductal and acinar...
19.
Bechard M, Bankaitis E, Ustione A, Piston D, Magnuson M, Wright C
Genesis
. 2017 Aug;
55(9).
PMID: 28772022
During pancreas organogenesis, Neurog3 endocrine-committing cells are generated from a population of Sox9 mitotic progenitors with only a low level of Neurog3 transcriptional activity (Neurog3 ). Low-level Neurog3 protein, in...
20.
Roy N, Takeuchi K, Ruggeri J, Bailey P, Chang D, Li J, et al.
Genes Dev
. 2017 Jan;
30(24):2669-2683.
PMID: 28087712
Aberrant activation of embryonic signaling pathways is frequent in pancreatic ductal adenocarcinoma (PDA), making developmental regulators therapeutically attractive. Here we demonstrate diverse functions for pancreatic and duodenal homeobox 1 (PDX1),...