Christopher R Gault
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Explore the profile of Christopher R Gault including associated specialties, affiliations and a list of published articles.
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11
Citations
869
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Recent Articles
1.
Trayssac M, Clarke C, Stith J, Snider J, Newen N, Gault C, et al.
Cell Death Dis
. 2021 Jan;
12(1):27.
PMID: 33414460
Senescence is an antiproliferative mechanism that can suppress tumor development and can be induced by oncogenes such as genes of the Ras family. Although studies have implicated bioactive sphingolipids (SL)...
2.
Nagra N, Burman B, Gault C, Dorer R, Siddique A
Cureus
. 2020 Aug;
12(7):e8976.
PMID: 32775058
Amyloidosis can affect multiple organs, and involvement of the heart is the most common cause of death. Signs and symptoms vary depending upon the organ system affected by amyloid. Liver...
3.
Lee H, Gault C, Cheng G, Shah J, Pantel A
Clin Nucl Med
. 2018 Dec;
44(2):150-152.
PMID: 30516688
A 34-year-old man with end-stage renal failure status post rejection of a deceased donor kidney transplant presented with bone pain in the setting of elevated serum parathyroid hormone and calcium...
4.
Gault C, Eblen S, Neumann C, Hannun Y, Obeid L
J Biol Chem
. 2012 Jul;
287(38):31794-803.
PMID: 22833671
Sphingosine kinase 1 (SK1) is an important enzyme involved in the production of the bioactive lipid sphingosine 1-phosphate (S1P). SK1 is overexpressed in many forms of cancer, however, the contribution...
5.
Gault C, Obeid L
Crit Rev Biochem Mol Biol
. 2011 Jul;
46(4):342-51.
PMID: 21787121
For several decades, lipid biologists have investigated how sphingolipids contribute to physiology, cell biology, and cell fate. Foremost among these discoveries is the finding that the bioactive sphingolipids ceramide, sphingosine,...
6.
Salas A, Ponnusamy S, Senkal C, Meyers-Needham M, Selvam S, Saddoughi S, et al.
Blood
. 2011 Apr;
117(22):5941-52.
PMID: 21527515
The mechanisms by which sphingosine kinase-1 (SK-1)/sphingosine 1-phosphate (S1P) activation contributes to imatinib resistance in chronic myeloid leukemia (CML) are unknown. We show herein that increased SK-1/S1P enhances Bcr-Abl1 protein...
7.
Jenkins R, Clarke C, Canals D, Snider A, Gault C, Heffernan-Stroud L, et al.
J Biol Chem
. 2011 Feb;
286(15):13292-303.
PMID: 21335555
Acid sphingomyelinase (aSMase) generates the bioactive lipid ceramide (Cer) from hydrolysis of sphingomyelin (SM). However, its precise roles in regulating specific sphingolipid-mediated biological processes remain ill defined. Interestingly, the aSMase...
8.
Gault C, Obeid L, Hannun Y
Adv Exp Med Biol
. 2010 Oct;
688:1-23.
PMID: 20919643
Sphingolipids constitute a class of lipids defined by their eighteen carbon amino-alcohol backbones which are synthesized in the ER from nonsphingolipid precursors. Modification of this basic structure is what gives...
9.
Anelli V, Gault C, Snider A, Obeid L
FASEB J
. 2010 Mar;
24(8):2727-38.
PMID: 20335228
Sphingosine-1-phosphate (S1P) is an important bioactive sphingolipid involved in angiogenesis and lymphangiogenesis, 2 important processes that influence the growth, survival, and spread of tumors. S1P acts as an extracellular mediator...
10.
Mahdy A, Cheng J, Li J, Elojeimy S, Meacham W, Turner L, et al.
Mol Ther
. 2008 Dec;
17(3):430-8.
PMID: 19107118
Radiation resistance in a subset of prostate tumors remains a challenge to prostate cancer radiotherapy. The current study on the effects of radiation on prostate cancer cells reveals that radiation...