Christopher McNair
Overview
Explore the profile of Christopher McNair including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
27
Citations
766
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0
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Recent Articles
11.
Leader A, McNair C, Yurick C, Huesser M, Schade E, Stimmel E, et al.
Cancer Epidemiol Biomarkers Prev
. 2022 Jan;
31(5):955-964.
PMID: 35064067
Background: Cancer centers are expected to engage communities and reduce the burden of cancer in their catchment areas. However, the extent to which cancer centers adequately reach the entire US...
12.
McCann J, Vasilevskaya I, McNair C, Gallagher P, Neupane N, de Leeuw R, et al.
Oncogene
. 2021 Nov;
41(3):444-458.
PMID: 34773073
The tumor suppressor gene TP53 is the most frequently mutated gene in numerous cancer types, including prostate cancer (PCa). Specifically, missense mutations in TP53 are selectively enriched in PCa, and...
13.
Bi X, Beadle D, Xu A, Neff J, DeGregorio N, Odeh M, et al.
JCO Clin Cancer Inform
. 2021 Nov;
5:1076-1084.
PMID: 34726955
Purpose: An important obstacle to cancer research is that nearly all academic cancer centers maintain substantial collections of highly duplicative, poorly quality-assured, nonintercommunicating, difficult-to-access data repositories. It is inherently clear...
14.
Stanek T, Gennaro V, Tracewell M, Di Marcantonio D, Pauley K, Butt S, et al.
EMBO J
. 2021 Jun;
40(16):e102509.
PMID: 34155658
The SAGA coactivator complex is essential for eukaryotic transcription and comprises four distinct modules, one of which contains the ubiquitin hydrolase USP22. In yeast, the USP22 ortholog deubiquitylates H2B, resulting...
15.
Mandigo A, Yuan W, Xu K, Gallagher P, Pang A, Guan Y, et al.
Cancer Discov
. 2021 Apr;
11(9):2334-2353.
PMID: 33879449
Loss of the retinoblastoma (RB) tumor suppressor protein is a critical step in reprogramming biological networks that drive cancer progression, although mechanistic insight has been largely limited to the impact...
16.
Welti J, Sharp A, Brooks N, Yuan W, McNair C, Chand S, et al.
Cancer Discov
. 2021 Jan;
11(5):1118-1137.
PMID: 33431496
Resistance to androgen receptor (AR) blockade in castration-resistant prostate cancer (CRPC) is associated with sustained AR signaling, including through alternative splicing of AR (AR-SV). Inhibitors of transcriptional coactivators that regulate...
17.
London J, Fazio-Eynullayeva E, Palchuk M, Sankey P, McNair C
JCO Clin Cancer Inform
. 2020 Jul;
4:657-665.
PMID: 32716647
Purpose: While there are studies under way to characterize the direct effects of the COVID-19 pandemic on the care of patients with cancer, there have been few quantitative reports of...
18.
McCann J, Vasilevskaya I, Neupane N, Shafi A, McNair C, Dylgjeri E, et al.
Cancer Res
. 2019 Nov;
80(3):430-443.
PMID: 31740444
Emerging evidence indicates the deubiquitinase USP22 regulates transcriptional activation and modification of target substrates to promote pro-oncogenic phenotypes. Here, characterization of tumor-associated USP22 upregulation and unbiased interrogation of USP22-regulated functions...
19.
Cosper P, McNair C, Gonzalez I, Wong N, Knudsen K, Chen J, et al.
Int J Cancer
. 2019 Nov;
146(7):2047-2058.
PMID: 31732968
More than one-third of patients with locally advanced cervical cancer do not respond to chemoradiation therapy (CRT). We aimed to characterize the transcriptional landscape of paired human cervical tumors before...
20.
Dylgjeri E, McNair C, Goodwin J, Raymon H, McCue P, Shafi A, et al.
Clin Cancer Res
. 2019 Jul;
25(18):5623-5637.
PMID: 31266833
Purpose: DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types and is strongly associated with...