Christopher M Read
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Explore the profile of Christopher M Read including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
288
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Recent Articles
1.
Dragan A, Read C, Crane-Robinson C
Eur Biophys J
. 2018 Dec;
48(2):131-138.
PMID: 30552448
The nature of water on the surface of a macromolecule is reflected in the temperature dependence of the heat effect, i.e., the heat capacity change, ΔCp, that accompanies its removal...
2.
Haensele E, Mele N, Miljak M, Read C, Whitley D, Banting L, et al.
J Chem Inf Model
. 2017 Jan;
57(2):298-310.
PMID: 28055189
Conformation and dynamics of the vasoconstrictive peptides human urotensin II (UII) and urotensin related peptide (URP) have been investigated by both unrestrained and enhanced-sampling molecular-dynamics (MD) simulations and NMR spectroscopy....
3.
Dragan A, Read C, Crane-Robinson C
Eur Biophys J
. 2016 Nov;
46(4):301-308.
PMID: 27796417
Structural modifications to interacting systems frequently lead to changes in both the enthalpy (heat) and entropy of the process that compensate each other, so that the Gibbs free energy is...
4.
Haensele E, Saleh N, Read C, Banting L, Whitley D, Clark T
J Chem Inf Model
. 2016 Sep;
56(9):1798-807.
PMID: 27585313
Arginine vasopressin (AVP) has been suggested by molecular-dynamics (MD) simulations to exist as a mixture of conformations in solution. The (1)H and (13)C NMR chemical shifts of AVP in solution...
5.
Arnold L, Butt L, Prior S, Read C, Fields G, Pickford A
J Biol Chem
. 2011 Oct;
286(52):45073-82.
PMID: 22030392
Matrix metalloproteinase-1 (MMP-1) is an instigator of collagenolysis, the catabolism of triple helical collagen. Previous studies have implicated its hemopexin (HPX) domain in binding and possibly destabilizing the collagen substrate...
6.
Phillips C, Roberts L, Schade M, Bazin R, Bent A, Davies N, et al.
J Am Chem Soc
. 2011 May;
133(25):9696-9.
PMID: 21612236
Synthetic peptides that specifically bind nuclear hormone receptors offer an alternative approach to small molecules for the modulation of receptor signaling and subsequent gene expression. Here we describe the design...
7.
Crane-Robinson C, Dragan A, Read C
Methods Mol Biol
. 2009 Apr;
543:625-51.
PMID: 19378190
Understanding the forces driving formation of protein/DNA complexes requires measurement of the Gibbs energy of association, DeltaG, and its component enthalpic, DeltaH, and entropic, DeltaS, contributions. Isothermal titration calorimetry provides...
8.
Favicchio R, Dragan A, Kneale G, Read C
Methods Mol Biol
. 2009 Apr;
543:589-611.
PMID: 19378154
Fluorescence spectroscopy can be used as a sensitive non-destructive technique for the characterisation of protein-DNA interactions. A comparison of the intrinsic emission spectra obtained for a protein-DNA complex and for...
9.
Dragan A, Read C, Makeyeva E, Milgotina E, Churchill M, Crane-Robinson C, et al.
J Mol Biol
. 2004 Sep;
343(2):371-93.
PMID: 15451667
To clarify the physical basis of DNA binding specificity, the thermodynamic properties and DNA binding and bending abilities of the DNA binding domains (DBDs) of sequence-specific (SS) and non-sequence-specific (NSS)...
10.
Simpson P, Monie T, Szendroi A, Davydova N, Tyzack J, Conte M, et al.
Structure
. 2004 Sep;
12(9):1631-43.
PMID: 15341728
The polypyrimidine tract binding protein (PTB) is an important regulator of alternative splicing that also affects mRNA localization, stabilization, polyadenylation, and translation. NMR structural analysis of the N-terminal half of...