Christopher M Mapes
Overview
Explore the profile of Christopher M Mapes including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
7
Citations
58
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Mapes C, Mani N, Deng X, Pandit C, McClure K, Pippel M, et al.
J Org Chem
. 2010 Oct;
75(22):7950-3.
PMID: 20977279
We describe a practical and scalable route to compound (Z)-1, a selective CCK1 receptor antagonist. Notable features of this concise route are (1) a regioselective construction of the pyrazole core...
2.
Pippel D, Mapes C, Mani N
J Org Chem
. 2007 Jun;
72(15):5828-31.
PMID: 17585818
Treatment of oxazole or 5-aryl oxazoles with i-PrMgCl smoothly generates the corresponding 2-Grignard reagents, which react with Weinreb amides to provide exclusively 2-acyl oxazole products.
3.
Mani N, Mapes C, Wu J, Deng X, Jones T
J Org Chem
. 2006 Jun;
71(13):5039-42.
PMID: 16776544
An efficient method for the stereoselective synthesis of (Z)-alpha-arylacrylates is described. Treatment of alpha-hydroxyesters with triflic anhydride and pyridine at 0 degrees C followed by warming to room temperature afforded...
4.
Leibowitz M, Ardecky R, Boehm M, Broderick C, Carfagna M, Crombie D, et al.
Endocrinology
. 2005 Nov;
147(2):1044-53.
PMID: 16269450
Specific retinoid X receptor (RXR) agonists, such as LG100268 (LG268), and the thiazolidinedione (TZD) PPARgamma agonists, such as rosiglitazone, produce insulin sensitization in rodent models of insulin resistance and type...
5.
Michellys P, DArrigo J, Grese T, Karanewsky D, Leibowitz M, Mais D, et al.
Bioorg Med Chem Lett
. 2004 Mar;
14(6):1593-8.
PMID: 15006411
The synthesis and in vitro characterization of novel RXR-selective ligands possessing various substituted 1-benzofuran or 1-benzothiophene moieties are described.
6.
Michellys P, Boehm M, Chen J, Grese T, Karanewsky D, Leibowitz M, et al.
Bioorg Med Chem Lett
. 2003 Nov;
13(22):4071-5.
PMID: 14592510
New RXR-selective modulators possessing a 6-fluoro trienoic acid moiety (6Z olefin) or a fluorinated/heterocyclic-substituted benzene core ring, were synthesized in an expedient and selective way. A subset of these compounds...
7.
Michellys P, Ardecky R, Chen J, DArrigo J, Grese T, Karanewsky D, et al.
J Med Chem
. 2003 Sep;
46(19):4087-103.
PMID: 12954061
Retinoid X receptor:peroxisome proliferative-activated receptor (RXR:PPAR) heterodimers play a critical role in the regulation of glucose (RXR/PPARgamma) and lipid metabolism (RXR/PPARalpha). Previously, we described a concise structure-activity relationship study of...