Christopher Koch
Overview
Explore the profile of Christopher Koch including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
292
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0
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Recent Articles
1.
Dominy J, Bai J, Koch C, Zaman Khan M, Khalid S, Chung J, et al.
PLoS Genet
. 2025 Mar;
21(3):e1011600.
PMID: 40043053
The single pass transmembrane protein CD33 is enriched in phagocytic and hematopoietic cell types, such as monocytes. CD33 is thought to be associated with immune cell function, susceptibility to Alzheimer's...
2.
Gurtan A, Khalid S, Koch C, Zaman Khan M, Lamarche L, Splawski I, et al.
Nat Metab
. 2024 Sep;
6(10):1913-1921.
PMID: 39327531
Growth differentiation factor 15 (GDF15) is a secreted protein that regulates food intake, body weight and stress responses in pre-clinical models. The physiological function of GDF15 in humans remains unclear....
3.
Dominy J, Koch C, Lamarche L, Denning D, Gurtan A, Khan M, et al.
N Engl J Med
. 2024 Apr;
390(16):1537-1538.
PMID: 38657259
No abstract available.
4.
5.
Hao L, Kraft P, Berriz G, Hynes E, Koch C, Korategere V Kumar P, et al.
Nat Med
. 2022 Apr;
28(5):1006-1013.
PMID: 35437332
Implementation of polygenic risk scores (PRS) may improve disease prevention and management but poses several challenges: the construction of clinically valid assays, interpretation for individual patients, and the development of...
6.
Klanderman B, Koch C, Machini K, Parpattedar S, Bandyadka S, Lin C, et al.
J Mol Diagn
. 2022 Jan;
24(3):205-218.
PMID: 35041930
Clinical laboratories offering genome sequencing have the opportunity to return pharmacogenomic findings to patients, providing the added benefit of preemptive testing that could help inform medication selection or dosing throughout...
7.
Zouk H, Yu W, Oza A, Hawley M, Vijay Kumar P, Koch C, et al.
Genet Med
. 2021 Dec;
24(2):454-462.
PMID: 34906510
Purpose: The clinical genomics knowledgebase is dynamic with variant classifications changing as newly identified cases, additional population data, and other evidence become available. This is a challenge for the clinical...
8.
Blout Zawatsky C, Shah N, Machini K, Perez E, Christensen K, Zouk H, et al.
Am J Hum Genet
. 2021 Nov;
108(12):2224-2237.
PMID: 34752750
Over 100 million research participants around the world have had research array-based genotyping (GT) or genome sequencing (GS), but only a small fraction of these have been offered return of...
9.
Nandadasa S, des Roziers C, Koch C, Tran-Lundmark K, Dours-Zimmermann M, Zimmermann D, et al.
Matrix Biol Plus
. 2021 Jul;
10:100064.
PMID: 34195596
Two inherent challenges in the mechanistic interpretation of protease-deficient phenotypes are defining the specific substrate cleavages whose reduction generates the phenotypes and determining whether the phenotypes result from loss of...
10.
Mehta T, Koch C, Nash W, Knaack S, Sudhakar P, Olbei M, et al.
Genome Biol
. 2021 Jan;
22(1):25.
PMID: 33419455
Background: Seminal studies of vertebrate protein evolution speculated that gene regulatory changes can drive anatomical innovations. However, very little is known about gene regulatory network (GRN) evolution associated with phenotypic...