Wanfeng Yu
Overview
Explore the profile of Wanfeng Yu including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
261
Followers
0
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Recent Articles
1.
Hao L, Kraft P, Berriz G, Hynes E, Koch C, Korategere V Kumar P, et al.
Nat Med
. 2022 Apr;
28(5):1006-1013.
PMID: 35437332
Implementation of polygenic risk scores (PRS) may improve disease prevention and management but poses several challenges: the construction of clinically valid assays, interpretation for individual patients, and the development of...
2.
Zouk H, Yu W, Oza A, Hawley M, Vijay Kumar P, Koch C, et al.
Genet Med
. 2021 Dec;
24(2):454-462.
PMID: 34906510
Purpose: The clinical genomics knowledgebase is dynamic with variant classifications changing as newly identified cases, additional population data, and other evidence become available. This is a challenge for the clinical...
3.
Yu W, Ni Y, Saji M, Ringel M, Jaini R, Eng C
Hum Mol Genet
. 2017 Feb;
26(7):1365-1375.
PMID: 28164237
Thyroid cancer is a major component cancer of Cowden syndrome (CS), a disorder typically associated with germline mutations in PTEN. Germline variants in succinate dehydrogenase genes (SDHx) co-occurring with PTEN...
4.
Wu Y, Xu J, El-Jouni W, Lu T, Li S, Wang Q, et al.
J Cell Sci
. 2016 Aug;
129(19):3675-3684.
PMID: 27505895
Mutation of PKD1, encoding the protein polycystin-1 (PC1), is the main cause of autosomal dominant polycystic kidney disease (ADPKD). The signaling pathways downstream of PC1 in ADPKD are still not...
5.
Ngeow J, Yu W, Yehia L, Niazi F, Chen J, Tang X, et al.
Gastroenterology
. 2015 Jul;
149(4):886-9.e5.
PMID: 26122142
Hamartomatous polyposis syndromes (HPS) account for a small but appreciable proportion of inherited gastrointestinal cancer predisposition syndromes; patients with HPS have an increased risk for colon and extracolonic malignancies. We...
6.
Yu W, He X, Ni Y, Ngeow J, Eng C
Hum Mol Genet
. 2014 Aug;
24(1):142-53.
PMID: 25149476
Germline mutations in the PTEN tumor-suppressor gene and germline variations in succinate dehydrogenase subunit D gene (SDHD-G12S, SDHD-H50R) are associated with a subset of Cowden syndrome and Cowden syndrome-like individuals...
7.
Tilot A, Gaugler M, Yu Q, Romigh T, Yu W, Miller R, et al.
Hum Mol Genet
. 2014 Jan;
23(12):3212-27.
PMID: 24470394
PTEN Hamartoma Tumor Syndrome (PHTS) is an autosomal-dominant genetic condition underlying a subset of autism spectrum disorder (ASD) with macrocephaly. Caused by germline mutations in PTEN, PHTS also causes increased...
8.
Yu W, Beaudry S, Negoro H, Boucher I, Tran M, Kong T, et al.
Proc Natl Acad Sci U S A
. 2012 Apr;
109(17):6680-5.
PMID: 22493269
The epithelial cell tight junction separates apical and basolateral domains and is essential for barrier function. Disruption of the tight junction is a hallmark of epithelial cell damage and can...
9.
Boucher I, Yu W, Beaudry S, Negoro H, Tran M, Pollak M, et al.
Lab Invest
. 2012 Jan;
92(5):662-75.
PMID: 22249312
Glomerulosclerosis is a common pathological finding that often progresses to renal failure. The mechanisms of chronic kidney disease progression are not well defined, but may include activation of numerous vasoactive...
10.
Yu W, Ritchie B, Su X, Zhou J, Meigs T, Denker B
Cell Signal
. 2010 Sep;
23(1):213-21.
PMID: 20837139
Most patients with autosomal dominant polycystic kidney disease (ADPKD) harbor mutations in PKD1, the gene for polycystin-1 (PC1), a transmembrane protein with a cytoplasmic C-terminus that interacts with numerous signaling...