Christopher J Porter
Overview
Explore the profile of Christopher J Porter including associated specialties, affiliations and a list of published articles.
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24
Citations
1480
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Recent Articles
1.
Saulnier O, Zagozewski J, Liang L, Hendrikse L, Layug P, Gordon V, et al.
Nat Cell Biol
. 2024 Jul;
26(8):1233-1246.
PMID: 39025928
OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and overexpressed in most cases of group 3 and group...
2.
Borlase S, DeCarlo A, Coudiere-Morrison L, Liang L, Porter C, Ramaswamy V, et al.
Cell Death Discov
. 2023 Sep;
9(1):347.
PMID: 37726268
Sonic Hedgehog (SHH) medulloblastomas (MBs) exhibit an intermediate prognosis and extensive intertumoral heterogeneity. While SHH pathway antagonists are effective in post-pubertal patients, younger patients exhibit significant side effects, and tumors...
3.
Zagozewski J, Borlase S, Guppy B, Coudiere-Morrison L, Shahriary G, Gordon V, et al.
Commun Biol
. 2022 Jul;
5(1):697.
PMID: 35835937
Medulloblastoma (MB) is the most common primary malignant pediatric brain cancer. We recently identified novel roles for the MEK/MAPK pathway in regulating human Sonic Hedgehog (SHH) MB tumorigenesis. The MEK...
4.
Vinas J, Spence M, Porter C, Douvris A, Gutsol A, Zimpelmann J, et al.
Kidney Int
. 2021 Jun;
100(3):597-612.
PMID: 34181969
Acute kidney injury (AKI) carries high morbidity and mortality, and effective treatments are lacking. Preclinical models support involvement of micro-RNAs (miRs) in AKI pathogenesis, although effects on the kidney transcriptome...
5.
Zagozewski J, Shahriary G, Morrison L, Saulnier O, Stromecki M, Fresnoza A, et al.
Nat Commun
. 2020 Jul;
11(1):3627.
PMID: 32686664
OTX2 is a potent oncogene that promotes tumor growth in Group 3 medulloblastoma. However, the mechanisms by which OTX2 represses neural differentiation are not well characterized. Here, we perform extensive...
6.
Vinas J, Porter C, Douvris A, Spence M, Gutsol A, Zimpelmann J, et al.
Clin Sci (Lond)
. 2020 Jul;
134(14):1887-1909.
PMID: 32662516
Female sex protects against development of acute kidney injury (AKI). While sex hormones may be involved in protection, the role of differential gene expression is unknown. We conducted gene profiling...
7.
Matsumoto S, Porter C, Ogasawara N, Iwatani C, Tsuchiya H, Seita Y, et al.
Sci Rep
. 2020 Apr;
10(1):6827.
PMID: 32321940
The placenta forms a maternal-fetal junction that supports many physiological functions such as the supply of nutrition and exchange of gases and wastes. Establishing an in vitro culture model of...
8.
Addicks G, Brun C, Sincennes M, Saber J, Porter C, Stewart A, et al.
Nat Commun
. 2019 Sep;
10(1):4256.
PMID: 31534153
PAX7 is a paired-homeobox transcription factor that specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. We previously found...
9.
Maganti H, Jrade H, Cafariello C, Manias Rothberg J, Porter C, Yockell-Lelievre J, et al.
Cancer Discov
. 2018 Aug;
8(11):1376-1389.
PMID: 30115703
Deep sequencing has revealed that epigenetic modifiers are the most mutated genes in acute myeloid leukemia (AML). Thus, elucidating epigenetic dysregulation in AML is crucial to understand disease mechanisms. Here,...
10.
Soleimani V, Nguyen D, Ramachandran P, Palidwor G, Porter C, Yin H, et al.
Nucleic Acids Res
. 2018 Jul;
46(14):7221-7235.
PMID: 30016497
Muscle-specific transcription factor MyoD orchestrates the myogenic gene expression program by binding to short DNA motifs called E-boxes within myogenic cis-regulatory elements (CREs). Genome-wide analyses of MyoD cistrome by chromatin...