Christopher J MacNevin
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Explore the profile of Christopher J MacNevin including associated specialties, affiliations and a list of published articles.
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11
Citations
403
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Recent Articles
1.
Mehl B, Vairaprakash P, Li L, Hinde E, MacNevin C, Hsu C, et al.
Cell Rep Methods
. 2024 Mar;
4(3):100734.
PMID: 38503289
In this work, we examine the use of environment-sensitive fluorescent dyes in fluorescence lifetime imaging microscopy (FLIM) biosensors. We screened merocyanine dyes to find an optimal combination of environment-induced lifetime...
2.
MacNevin C, Watanabe T, Weitzman M, Gulyani A, Fuehrer S, Pinkin N, et al.
J Am Chem Soc
. 2019 Apr;
141(18):7275-7282.
PMID: 30994345
Dyes with environment-sensitive fluorescence have proven useful to study the spatiotemporal dynamics of protein activity in living cells. When attached to proteins, their fluorescence can reflect protein conformational changes, post-translational...
3.
Liu R, Liu M, Hood D, Chen C, MacNevin C, Holten D, et al.
Molecules
. 2018 Jan;
23(1).
PMID: 29320445
Fluorophores that absorb and emit in the red spectral region (600-700 nm) are of great interest in photochemistry and photomedicine. Eight new target chlorins (and 19 new chlorins altogether)-analogues of...
4.
Ye F, Yang C, Kim J, MacNevin C, Hahn K, Park D, et al.
J Biol Chem
. 2017 May;
292(24):9858-9864.
PMID: 28487468
Epigallocatechin gallate (EGCG) is the principal bioactive ingredient in green tea and has been reported to have many health benefits. EGCG influences multiple signal transduction pathways related to human diseases,...
5.
MacNevin C, Toutchkine A, Marston D, Hsu C, Tsygankov D, Li L, et al.
J Am Chem Soc
. 2016 Feb;
138(8):2571-5.
PMID: 26863024
Biosensors that report endogenous protein activity in vivo can be based on environment-sensing fluorescent dyes. The dyes can be attached to reagents that bind selectively to a specific conformation of...
6.
Helassa N, Garnett J, Farrant M, Khan F, Pickup J, Hahn K, et al.
Biochem J
. 2014 Sep;
464(2):213-20.
PMID: 25220254
Both lung disease and elevation of blood glucose are associated with increased glucose concentration (from 0.4 to ~4.0 mM) in the airway surface liquid (ASL). This perturbation of ASL glucose...
7.
Konze K, Ma A, Li F, Barsyte-Lovejoy D, Parton T, MacNevin C, et al.
ACS Chem Biol
. 2013 Apr;
8(6):1324-34.
PMID: 23614352
EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a transcriptionally...
8.
MacNevin C, Gremyachinskiy D, Hsu C, Li L, Rougie M, Davis T, et al.
Bioconjug Chem
. 2013 Jan;
24(2):215-23.
PMID: 23297747
Fluorescent biosensors based on environmentally sensitive dyes enable visualization and quantification of endogenous protein activation within living cells. Merocyanine dyes are especially useful for live cell imaging applications, as they...
9.
James L, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh V, Herold J, et al.
Nat Chem Biol
. 2013 Jan;
9(3):184-91.
PMID: 23292653
We describe the discovery of UNC1215, a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of...
10.
MacNevin C, Atif F, Sayeed I, Stein D, Liotta D
J Med Chem
. 2009 Oct;
52(19):6012-23.
PMID: 19791804
Preclinical and clinical research findings have revealed that the hormone progesterone, when acutely administered, can dramatically reduce cerebral edema, inflammation, tissue necrosis, and programmed cell death following traumatic brain injury...