Christopher D McNitt
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Explore the profile of Christopher D McNitt including associated specialties, affiliations and a list of published articles.
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12
Citations
96
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Recent Articles
1.
Sun L, Gai Y, McNitt C, Sun J, Zhang X, Xing W, et al.
J Org Chem
. 2020 Apr;
85(9):5771-5777.
PMID: 32223160
A novel photo-click-based platform has been developed for rapid screening and affinity optimization of heterobivalent agents. This method allows for the efficient selection of high-affinity dual receptor-targeting agents streamlining tedious...
2.
Wang M, McNitt C, Wang H, Ma X, Scarry S, Wu Z, et al.
Chem Commun (Camb)
. 2018 Jun;
54(56):7810-7813.
PMID: 29946609
Here we report the 18F labeling of a prostate specific membrane antigen (PSMA) ligand via a strain promoted oxa-dibenzocyclooctyne (ODIBO)- or bicyclo[6.1.0]nonyne (BCN)-azide reaction. Although ODIBO reacts with azide 20...
3.
Boudjemeline M, McNitt C, Singleton T, Popik V, Kostikov A
Org Biomol Chem
. 2017 Nov;
16(3):363-366.
PMID: 29170778
A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [F]oxadibenzocyclooctyne ([F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides...
4.
McNitt C, Cheng H, Ullrich S, Popik V, Bjerknes M
J Am Chem Soc
. 2017 Sep;
139(40):14029-14032.
PMID: 28925255
Irradiation of cyclopropenone-masked dibenzocyclooctynes with near-infrared pulses from a femtosecond laser triggers photodecarbonylation via nonresonant two- or three-photon excitation. Multiphoton-generated cyclooctynes undergo a SPAAC reaction with organic azides, yielding the...
5.
Bjerknes M, Cheng H, McNitt C, Popik V
Bioconjug Chem
. 2017 Apr;
28(5):1560-1565.
PMID: 28437092
Little is known about the reactivity of strain-promoted alkyne-azide cycloaddition (SPAAC) reagents with inorganic azides. We explore the reactions of a variety of popular SPAAC reagents with sodium azide and...
6.
Whitehead S, McNitt C, Mattern-Schain S, Carr A, Alam S, Popik V, et al.
Bioconjug Chem
. 2017 Mar;
28(4):923-932.
PMID: 28248084
Artificial systems for controlled membrane fusion applicable for drug delivery would ideally use triggers that are orthogonal to biology. To apply the strain-promoted alkyne-azide cycloaddition (SPAAC) to drive membrane fusion,...
7.
Luo W, Gobbo P, McNitt C, Sutton D, Popik V, Workentin M
Chemistry
. 2016 Oct;
23(5):1052-1059.
PMID: 27727488
In this study, we report the design, synthesis, and characterization of small 3 nm water soluble gold nanoparticles (AuNPs) that feature cyclopropenone-masked strained alkyne moieties capable of undergoing interfacial strain-promoted...
8.
Durie K, Yatvin J, McNitt C, Reese R, Jung C, Popik V, et al.
Langmuir
. 2016 Jun;
32(26):6600-5.
PMID: 27280689
Polymer brushes are excellent substrates for the covalent immobilization of a wide variety of molecules due to their unique physicochemical properties and high functional group density. By using reactive microcapillary...
9.
Alam S, Alves D, Whitehead S, Bayer A, McNitt C, Popik V, et al.
Bioconjug Chem
. 2015 May;
26(6):1021-31.
PMID: 25927978
For drug delivery purposes, the ability to conveniently attach a targeting moiety that will deliver drugs to cells and then enable controlled release of the active molecule after localization is...
10.
Pathak R, McNitt C, Popik V, Dhar S
Chemistry
. 2014 Apr;
20(23):6861-5.
PMID: 24756923
The ability to rationally design and construct a platform technology to develop new platinum(IV) [Pt(IV)] prodrugs with functionalities for installation of targeting moieties, delivery systems, fluorescent reporters from a single...