[F]ODIBO: a Prosthetic Group for Bioorthogonal Radiolabeling of Macromolecules Via Strain-promoted Alkyne-azide Cycloaddition

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2017 Nov 25

PMID 29170778

Citations 6

Authors

Mehdi Boudjemeline

Christopher D McNitt

Thomas A Singleton

Vladimir V Popik

Alexey P Kostikov

Affiliations

Soon will be listed here.

Abstract

A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [F]oxadibenzocyclooctyne ([F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts.

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