Christopher B Umbricht
Overview
Explore the profile of Christopher B Umbricht including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
49
Citations
1426
Followers
0
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Recent Articles
1.
Debeljak M, Cho S, Downs B, Considine M, Avin-McKelvey B, Wang Y, et al.
Breast Cancer Res
. 2024 Dec;
26(1):178.
PMID: 39633428
Background: Ductal carcinoma in-situ (DCIS) is a pre-invasive form of invasive breast cancer (IBC). Due to improved breast cancer screening, it now accounts for ~ 25% of all breast cancers....
2.
Powell B, Turchinovich A, Wang Y, Gololobova O, Buschmann D, Zeiger M, et al.
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36901936
Hypoxia, or low oxygen tension, is frequently found in highly proliferative solid tumors such as anaplastic thyroid carcinoma (ATC) and is believed to promote resistance to chemotherapy and radiation. Identifying...
3.
Visvanathan K, Cope L, Fackler M, Considine M, Sokoll L, Carey L, et al.
Clin Cancer Res
. 2022 Dec;
29(4):784-790.
PMID: 36534524
Purpose: We previously demonstrated that high levels of circulating methylated DNA are associated with subsequent disease progression in women with metastatic breast cancer (MBC). In this study, we evaluated the...
4.
Fackler M, Tulac S, Venkatesan N, Aslam A, de Guzman T, Mercado-Rodriguez C, et al.
Cancer Res Commun
. 2022 Sep;
2(6):391-401.
PMID: 36046124
Current molecular liquid biopsy assays to detect recurrence or monitor response to treatment require sophisticated technology, highly trained personnel, and a turnaround time of weeks. We describe the development and...
5.
Wang Y, McKelvey B, Liu Z, Rooper L, Cope L, Zeiger M, et al.
J Cancer Res Clin Oncol
. 2021 Jun;
147(10):2983-2991.
PMID: 34165589
Background: While molecular testing is a promising strategy for preoperative assessment of cytologically indeterminate thyroid nodules, thyroid fine needle aspiration biopsy (FNA) presents unique challenges for molecular assays, including contaminating...
6.
Downs B, Ding W, Cope L, Umbricht C, Li W, He H, et al.
Clin Epigenetics
. 2021 May;
13(1):104.
PMID: 33952317
Background: Definitive diagnosis of primary central nervous system lymphoma (PCNSL) requires invasive surgical brain biopsy, causing treatment delays. In this paper, we identified and validated tumor-specific markers that can distinguish...
7.
McKelvey B, Zeiger M, Umbricht C
Genes Chromosomes Cancer
. 2020 Dec;
60(6):403-409.
PMID: 33305870
Alterations in the genome, including mutations and copy number variation (CNV), can drive cancer progression. The Cancer Genome Atlas (TCGA) project studying papillary thyroid cancer (PTC) identified a number of...
8.
Jacobs M, Umbricht C, Parekh V, El Khouli R, Cope L, Macura K, et al.
Cancers (Basel)
. 2020 Sep;
12(10).
PMID: 32992569
Optimal use of multiparametric magnetic resonance imaging (mpMRI) can identify key MRI parameters and provide unique tissue signatures defining phenotypes of breast cancer. We have developed and implemented a new...
9.
McKelvey B, Zeiger M, Umbricht C
Mol Oncol
. 2020 Sep;
14(10):2355-2357.
PMID: 32920953
Telomerase regulation, including TERT promoter methylation, has been of long-standing interest to cancer biologists. Rowland et al. have now vastly expanded their ongoing characterization of TERT promoter methylation in cancer...
10.
McKelvey B, Umbricht C, Zeiger M
Front Endocrinol (Lausanne)
. 2020 Aug;
11:485.
PMID: 32849278
is the catalytic subunit of the enzyme telomerase and is essential for telomerase activity. Upregulation of expression and resulting telomerase activity occurs in the large majority of malignancies, including thyroid...