Christopher B Umbricht
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Explore the profile of Christopher B Umbricht including associated specialties, affiliations and a list of published articles.
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49
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1426
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Recent Articles
11.
Tan J, Liu R, Zhu G, Umbricht C, Xing M
Proc Natl Acad Sci U S A
. 2020 Jun;
117(27):15846-15851.
PMID: 32561648
Combination use of BRAF V600E inhibitor dabrafenib and MEK inhibitor trametinib has become a standard treatment for human cancers harboring V600E. Its anticancer efficacies vary, however, with dramatic efficacy in...
12.
McKelvey B, Gilpatrick T, Wang Y, Timp W, Umbricht C, Zeiger M
Thyroid
. 2020 Apr;
30(10):1470-1481.
PMID: 32228178
Telomerase reverse transcriptase () promoter mutations play a role in carcinogenesis and are found in both tumors and cancer cell lines. promoter methylation, transcription factor binding, chromatin remodeling, and alternative...
13.
Fackler M, Cho S, Cope L, Gabrielson E, Visvanathan K, Wilsbach K, et al.
NPJ Breast Cancer
. 2020 Feb;
6:3.
PMID: 32025567
We lack tools to risk-stratify triple-negative breast cancer (TNBC). Our goal was to develop molecular tools to predict disease recurrence. Methylation array analysis was performed on 110 samples treated by...
14.
Weng C, Okawa E, Roberts M, Park S, Umbricht C, Manson J, et al.
Thyroid
. 2020 Jan;
30(4):519-530.
PMID: 31918623
The association between thyroid disorders and breast cancer remains controversial, in part, due to small cohort sizes and inconsistent findings. We investigated this association in postmenopausal women to determine whether...
15.
Downs B, Mercado-Rodriguez C, Cimino-Mathews A, Chen C, Yuan J, Van Den Berg E, et al.
Clin Cancer Res
. 2019 Jul;
25(21):6357-6367.
PMID: 31300453
Purpose: An unmet need in low-resource countries is an automated breast cancer detection assay to prioritize women who should undergo core breast biopsy and pathologic review. Therefore, we sought to...
16.
Cho S, Kim H, Zeiger M, Umbricht C, Cope L
J Comput Biol
. 2019 Feb;
26(4):295-304.
PMID: 30789293
Genetic and epigenetic changes drive carcinogenesis, and their integrated analysis provides insights into mechanisms of cancer development. Computational methods have been developed to measure copy number variation (CNV) from methylation...
17.
Avin B, Wang Y, Gilpatrick T, Workman R, Lee I, Timp W, et al.
Genes Chromosomes Cancer
. 2019 Jan;
58(8):530-540.
PMID: 30664813
Telomerase reverse transcriptase (TERT) activation plays an important role in cancer development by enabling the immortalization of cells. TERT regulation is multifaceted, and its promoter methylation has been implicated in...
18.
Liu Z, Sahli Z, Wang Y, Wolff A, Cope L, Umbricht C
Breast Cancer Res Treat
. 2018 Sep;
172(3):689-702.
PMID: 30225619
Purpose: Although age is a recognized independent prognostic risk factor, its relative importance among molecular subtypes of Breast cancer (BCA) is not well documented. The aim of this study was...
19.
Sahli Z, Smith P, Umbricht C, Zeiger M
Front Endocrinol (Lausanne)
. 2018 May;
9:179.
PMID: 29720964
The need for distinguishing benign from malignant thyroid nodules has led to the pursuit of differentiating molecular markers. The most common molecular tests in clinical use are Afirma Gene Expression...
20.
Sahli Z, Umbricht C, Schneider E, Zeiger M
Thyroid
. 2017 Sep;
27(11):1393-1399.
PMID: 28859553
Background: Current thyroid molecular tests are specifically designed for the differential diagnosis of nodules with indeterminate or suspicious fine-needle aspiration (FNA) cytology. Summary: However, their clinical validity faces challenges from...