Christopher B Phelps
Overview
Explore the profile of Christopher B Phelps including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
650
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0
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Recent Articles
1.
Deng J, Belyanskaya S, Prabhu N, Arico-Muendel C, Deng H, Phelps C, et al.
SLAS Discov
. 2024 Jun;
29(5):100171.
PMID: 38917882
DNA-encoded small molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, it has been used to identify ligands against targets that...
2.
Zhu Z, Grady L, Ding Y, Lind K, Davie C, Phelps C, et al.
SLAS Discov
. 2018 Nov;
24(2):169-174.
PMID: 30383465
DNA-encoded libraries (DELs) have been broadly applied to identify chemical probes for target validation and lead discovery. To date, the main application of the DEL platform has been the identification...
3.
Machutta C, Kollmann C, Lind K, Bai X, Chan P, Huang J, et al.
Nat Commun
. 2018 Jul;
9:16227.
PMID: 30004092
This corrects the article DOI: 10.1038/ncomms16081.
4.
Leveridge M, Chung C, Gross J, Phelps C, Green D
SLAS Discov
. 2018 Jun;
23(9):881-897.
PMID: 29874524
There has been much debate around the success rates of various screening strategies to identify starting points for drug discovery. Although high-throughput target-based and phenotypic screening has been the focus...
5.
Machutta C, Kollmann C, Lind K, Bai X, Chan P, Huang J, et al.
Nat Commun
. 2017 Jul;
8:16081.
PMID: 28714473
The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins...
6.
Lu X, Fan L, Phelps C, Davie C, Donahue C
Bioconjug Chem
. 2017 Jun;
28(6):1625-1629.
PMID: 28581718
DNA-encoded library technology (ELT) is now widely used in pharmaceutical, biotechnological, and academic research for hit identification and target validation. New on-DNA reactions are keys to exploring greater chemical space...
7.
Landoure G, Zdebik A, Martinez T, Burnett B, Stanescu H, Inada H, et al.
Nat Genet
. 2009 Dec;
42(2):170-4.
PMID: 20037586
Charcot-Marie-Tooth disease type 2C (CMT2C) is an autosomal dominant neuropathy characterized by limb, diaphragm and laryngeal muscle weakness. Two unrelated families with CMT2C showed significant linkage to chromosome 12q24.11. We...
8.
Phelps C, Wang R, Choo S, Gaudet R
J Biol Chem
. 2009 Oct;
285(1):731-40.
PMID: 19864432
Transient receptor potential vanilloid (TRPV) channels, which include the thermosensitive TRPV1-V4, have large cytoplasmic regions flanking the transmembrane domain, including an N-terminal ankyrin repeat domain. We show that a multiligand...
9.
Phelps C, Procko E, Lishko P, Wang R, Gaudet R
Channels (Austin)
. 2008 Aug;
1(3):148-51.
PMID: 18690026
Ion channels are often modulated by intracellular calcium levels. TRPV1, a channel responsible for the burning pain sensation in response to heat, acid or capsaicin, is desensitized at high intracellular...
10.
Phelps C, Huang R, Lishko P, Wang R, Gaudet R
Biochemistry
. 2008 Feb;
47(8):2476-84.
PMID: 18232717
Transient receptor potential (TRP) proteins are cation channels composed of a transmembrane domain flanked by large N- and C-terminal cytoplasmic domains. All members of the vanilloid family of TRP channels...