Christine P Donahue
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Explore the profile of Christine P Donahue including associated specialties, affiliations and a list of published articles.
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13
Citations
771
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Recent Articles
1.
Machutta C, Kollmann C, Lind K, Bai X, Chan P, Huang J, et al.
Nat Commun
. 2018 Jul;
9:16227.
PMID: 30004092
This corrects the article DOI: 10.1038/ncomms16081.
2.
Machutta C, Kollmann C, Lind K, Bai X, Chan P, Huang J, et al.
Nat Commun
. 2017 Jul;
8:16081.
PMID: 28714473
The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins...
3.
Lu X, Fan L, Phelps C, Davie C, Donahue C
Bioconjug Chem
. 2017 Jun;
28(6):1625-1629.
PMID: 28581718
DNA-encoded library technology (ELT) is now widely used in pharmaceutical, biotechnological, and academic research for hit identification and target validation. New on-DNA reactions are keys to exploring greater chemical space...
4.
Liu Y, Peacey E, Dickson J, Donahue C, Zheng S, Varani G, et al.
J Med Chem
. 2009 Oct;
52(21):6523-6.
PMID: 19839622
A series of mitoxantrone (MTX) analogues have been designed, synthesized, and evaluated for binding to and stabilizing a stem-loop structure that serves as a splicing regulatory element in the pre-mRNA...
5.
Zheng S, Chen Y, Donahue C, Wolfe M, Varani G
Chem Biol
. 2009 May;
16(5):557-66.
PMID: 19477420
Some familial neurodegenerative diseases are associated with mutations that destabilize a putative stem-loop structure within an intronic region of the tau pre-messenger RNA (mRNA) and alter the production of tau...
6.
Donahue C, Ni J, Rozners E, Glicksman M, Wolfe M
J Biomol Screen
. 2007 May;
12(6):789-99.
PMID: 17525136
Alternative splicing of tau exon 10 produces tau isoforms with either 3 (3R) or 4 (4R) repeated microtubule-binding domains. Increased ratios of 4R to 3R tau expression, above the physiological...
7.
Donahue C, Muratore C, Wu J, Kosik K, Wolfe M
J Biol Chem
. 2006 Jun;
281(33):23302-6.
PMID: 16782711
Neurofibrillary tangles containing filaments of the microtubule-associated protein tau are found in a variety of neurodegenerative diseases. Mutations in the tau gene itself cause frontotemporal dementia with parkinsonism, demonstrating the...
8.
Donahue C, Kosik K, Shors T
Proc Natl Acad Sci U S A
. 2006 Apr;
103(15):6031-6.
PMID: 16574776
Recent studies by our group and others have demonstrated that growth hormone (GH) is produced endogenously within the hippocampal formation, a brain structure associated with learning and aspects of emotional...
9.
Arboleda-Velasquez J, Rampal R, Fung E, Darland D, Liu M, Martinez M, et al.
Hum Mol Genet
. 2005 Apr;
14(12):1631-9.
PMID: 15857853
Mutations in the NOTCH3 gene trigger adult-onset stroke and vascular dementia in patients with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). All CADASIL mutations described to date...
10.
Kosik K, Donahue C, Israely I, Liu X, Ochiishi T
Trends Cell Biol
. 2005 Mar;
15(3):172-8.
PMID: 15752981
Delta-catenin belongs to the p120-catenin (p120(ctn)) protein family, which is characterized by ten, characteristically spaced Armadillo repeats that bind to the juxtamembrane segment of the classical cadherins. Delta-catenin is the...