Christoph Wulfing
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Explore the profile of Christoph Wulfing including associated specialties, affiliations and a list of published articles.
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43
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1099
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Recent Articles
1.
Lu J, Veler A, Simonetti B, Raj T, Chou P, Cross S, et al.
Cells
. 2023 Nov;
12(21).
PMID: 37947636
T cells can express multiple inhibitory receptors. Upon induction of T cell exhaustion in response to a persistent antigen, prominently in the anti-tumor immune response, many are expressed simultaneously. Key...
2.
Lu J, Veler A, Simonetti B, Raj T, Chou P, Cross S, et al.
bioRxiv
. 2023 Jul;
PMID: 37503045
T cells can express multiple inhibitory receptors. Upon induction of T cell exhaustion in response to persistent antigen, prominently in the anti-tumor immune response, many are expressed simultaneously. Key inhibitory...
3.
4.
Edmunds G, Wong C, Ambler R, Milodowski E, Alamir H, Cross S, et al.
Commun Biol
. 2022 Jan;
5(1):9.
PMID: 35013519
Tumors generate an immune-suppressive environment that prevents effective killing of tumor cells by CD8 cytotoxic T cells (CTL). It remains largely unclear upon which cell type and at which stage...
5.
Li Y, Tunbridge H, Britton G, Hill E, Sinai P, Cirillo S, et al.
Cells
. 2021 Mar;
10(2).
PMID: 33671236
Peripheral immune regulation is critical for the maintenance of self-tolerance. Here we have investigated signaling processes that distinguish T cells with regulatory capability from effector T cells. The murine Tg4...
6.
Tan S, Alibhai D, Cross S, Thompson H, Wulfing C
Bio Protoc
. 2021 Mar;
10(21):e3806.
PMID: 33659460
Supramolecular signaling assemblies are of interest for their unique signaling properties. A µm scale signaling assembly, the central supramolecular signaling cluster (cSMAC), forms at the center interface of T cells...
7.
Ambler R, Edmunds G, Tan S, Cirillo S, Pernes J, Ruan X, et al.
Sci Signal
. 2020 Sep;
13(649).
PMID: 32934075
The killing of tumor cells by CD8 T cells is suppressed by the tumor microenvironment, and increased expression of inhibitory receptors, including programmed cell death protein-1 (PD-1), is associated with...
8.
Clark D, McMillan L, Tan S, Bellomo G, Massoue C, Thompson H, et al.
Elife
. 2019 Oct;
8.
PMID: 31663508
Supramolecular signaling assemblies are of interest for their unique signaling properties. A µm scale signaling assembly, the central supramolecular signaling cluster (cSMAC), forms at the center of the interface of...
9.
Ruan X, Wulfing C, Murphy R
Bioinformatics
. 2017 Sep;
33(14):i217-i224.
PMID: 28881992
Motivation: Efforts to model how signaling and regulatory networks work in cells have largely either not considered spatial organization or have used compartmental models with minimal spatial resolution. Fluorescence microscopy...
10.
Ambler R, Ruan X, Murphy R, Wulfing C
Methods Mol Biol
. 2017 Mar;
1584:409-421.
PMID: 28255716
Three-dimensional live cell imaging of the interaction of T cells with antigen-presenting cells (APCs) visualizes the subcellular distributions of signaling intermediates during T cell activation at thousands of resolved positions...