Christoph Loenarz
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Explore the profile of Christoph Loenarz including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
1914
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0
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Recent Articles
1.
Eisenbeis V, Qiu D, Gorka O, Strotmann L, Liu G, Prucker I, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(34):e2306868120.
PMID: 37579180
Inositol pyrophosphates (PP-InsPs) are energetic signaling molecules with important functions in mammals. As their biosynthesis depends on ATP concentration, PP-InsPs are tightly connected to cellular energy homeostasis. Consequently, an increasing...
2.
Bencic P, Keppler M, Kuge M, Qiu D, Schutte L, Haner M, et al.
FEBS J
. 2023 Jun;
290(20):4899-4920.
PMID: 37329249
Recent advances in mRNA therapeutics demand efficient toolkits for the incorporation of nucleoside analogues into mRNA suitable for downstream applications. Herein, we report the application of a versatile enzyme cascade...
3.
Gericke L, Mhaindarkar D, Karst L, Jahn S, Kuge M, Mohr M, et al.
Chembiochem
. 2023 Mar;
24(9):e202300133.
PMID: 36942622
S-Adenosylmethionine (SAM) is an enzyme cofactor involved in methylation, aminopropyl transfer, and radical reactions. This versatility renders SAM-dependent enzymes of great interest in biocatalysis. The usage of SAM analogues adds...
4.
Gagsteiger J, Jahn S, Heidinger L, Gericke L, Andexer J, Friedrich T, et al.
Angew Chem Int Ed Engl
. 2022 May;
61(32):e202204198.
PMID: 35638156
Methyl-coenzyme M reductase, which is responsible for the production of the greenhouse gas methane during biological methane formation, carries several unique posttranslational amino acid modifications, including a 2-(S)-methylglutamine. The enzyme...
5.
Loenarz C
Angew Chem Int Ed Engl
. 2020 Jan;
59(10):3776-3780.
PMID: 31961479
The 2019 Nobel Prize in Physiology or Medicine honours three scientists that devoted their careers to pursuing an audacious basic science question: by what mechanisms do animals sense oxygen, and...
6.
Lippl K, Boleininger A, McDonough M, Abboud M, Tarhonskaya H, Chowdhury R, et al.
Hypoxia (Auckl)
. 2018 Dec;
6:57-71.
PMID: 30519597
Background: In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that counteract the effects of limiting...
7.
Thinnes C, Lohans C, Abboud M, Yeh T, Tumber A, Nowak R, et al.
Chemistry
. 2018 Nov;
25(8):2019-2024.
PMID: 30427558
Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective...
8.
Abboud M, Chowdhury R, Leung I, Lippl K, Loenarz C, Claridge T, et al.
Chembiochem
. 2018 Aug;
19(21):2262-2267.
PMID: 30144273
In animals, the response to chronic hypoxia is mediated by upregulation of the α,β-heterodimeric hypoxia-inducible factors (HIFs). Levels of HIFα isoforms, but not HIFβ, are regulated by their post-translational modification...
9.
Sekirnik R, Wilkins S, Bush J, Tarhonskaya H, Munzel M, Hussein A, et al.
Extremophiles
. 2018 Mar;
22(3):553-562.
PMID: 29523972
YcfD from Escherichia coli is a homologue of the human ribosomal oxygenases NO66 and MINA53, which catalyse histidyl-hydroxylation of the 60S subunit and affect cellular proliferation (Ge et al., Nat...
10.
Longbotham J, Levy C, Johannissen L, Tarhonskaya H, Jiang S, Loenarz C, et al.
Biochemistry
. 2015 Sep;
54(39):6093-105.
PMID: 26368022
The Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenases comprise a large and diverse enzyme superfamily the members of which have multiple physiological roles. Despite this diversity, these enzymes share a common chemical...