Christoffel Dinant
Overview
Explore the profile of Christoffel Dinant including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
23
Citations
1181
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0
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Recent Articles
1.
Fogde D, Xavier C, Balnyte K, Holland L, Stahl-Meyer K, Dinant C, et al.
Cells
. 2022 Dec;
11(24).
PMID: 36552844
Cancer is one of the leading causes of death worldwide, thus the search for new cancer therapies is of utmost importance. Ursolic acid is a naturally occurring pentacyclic triterpene with...
2.
Gomez-Cabello D, Pappas G, Aguilar-Morante D, Dinant C, Bartek J
Nat Commun
. 2022 Sep;
13(1):5303.
PMID: 36085345
The RNA world is changing our views about sensing and resolution of DNA damage. Here, we develop single-molecule DNA/RNA analysis approaches to visualize how nascent RNA facilitates the repair of...
3.
Bredahl Hansen M, Postol M, Tvingsholm S, Nielsen I, Dietrich T, Puustinen P, et al.
Cell Oncol (Dordr)
. 2021 May;
44(4):805-820.
PMID: 33939112
Purpose: Most HER2 positive invasive cancers are either intrinsic non-responsive or develop resistance when treated with 1st line HER2 targeting drugs. Both 1st and 2nd line treatments of HER2 positive...
4.
Obara E, Aguilar-Morante D, Rasmussen R, Frias A, Vitting-Serup K, Lim Y, et al.
Nat Commun
. 2020 Sep;
11(1):4709.
PMID: 32948765
Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for glioblastoma patients. Mechanisms underpinning radio-resistance of GSCs remain largely unknown. Chromatin state and...
5.
Lopez-Saavedra A, Gomez-Cabello D, Dominguez-Sanchez M, Mejias-Navarro F, Fernandez-Avila M, Dinant C, et al.
Nat Commun
. 2016 Aug;
7:12364.
PMID: 27503537
There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous recombination. Here we identify and characterize novel factors involved in choosing between these pathways;...
6.
Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, et al.
Mol Cell
. 2013 Aug;
51(4):469-79.
PMID: 23973375
Chromatin remodeling is tightly linked to all DNA-transacting activities. To study chromatin remodeling during DNA repair, we established quantitative fluorescence imaging methods to measure the exchange of histones in chromatin...
7.
Bennetzen M, Larsen D, Dinant C, Watanabe S, Bartek J, Lukas J, et al.
Cell Cycle
. 2013 May;
12(11):1688-95.
PMID: 23656789
Genotoxic insults, such as ionizing radiation (IR), cause DNA damage that evokes a multifaceted cellular DNA damage response (DDR). DNA damage signaling events that control protein activity, subcellular localization, DNA...
8.
Dinant C, Bartek J, Bekker-Jensen S
Int J Mol Sci
. 2012 Dec;
13(10):13322-37.
PMID: 23202955
Nucleotide excision repair (NER) is an important DNA repair mechanism required for cellular resistance against UV light and toxic chemicals such as those found in tobacco smoke. In living cells,...
9.
Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grofte M, et al.
Cell
. 2012 Aug;
150(4):697-709.
PMID: 22884692
Histone ubiquitylation is a prominent response to DNA double-strand breaks (DSBs), but how these modifications are confined to DNA lesions is not understood. Here, we show that TRIP12 and UBR5,...
10.
Bergink S, Toussaint W, Luijsterburg M, Dinant C, Alekseev S, Hoeijmakers J, et al.
J Cell Biol
. 2012 Mar;
196(6):681-8.
PMID: 22431748
The recognition of helix-distorting deoxyribonucleic acid (DNA) lesions by the global genome nucleotide excision repair subpathway is performed by the XPC-RAD23-CEN2 complex. Although it has been established that Rad23 homologs...