Christine L Powell
Overview
Explore the profile of Christine L Powell including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
390
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Recent Articles
1.
Aylor D, Valdar W, Foulds-Mathes W, Buus R, Verdugo R, Baric R, et al.
Genome Res
. 2011 Mar;
21(8):1213-22.
PMID: 21406540
The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being developed as a resource for mammalian systems genetics. Here we describe an experiment that uses partially...
2.
Powell C, Bradford B, Craig C, Tsuchiya M, Uehara T, OConnell T, et al.
Toxicol Sci
. 2010 Feb;
115(1):131-9.
PMID: 20118189
Alcohol-induced liver injury (ALI) has been associated with, among other molecular changes, abnormal hepatic methionine metabolism, resulting in decreased levels of S-adenosylmethionine (SAM). Dietary methyl donor supplements such as SAM...
3.
Bagnyukova T, Powell C, Pavliv O, Tryndyak V, Pogribny I
Brain Res
. 2008 Aug;
1237:44-51.
PMID: 18694737
The age-associated decline in cellular antioxidant defenses and resultant accumulation of DNA damage in central nervous system has been mechanistically implicated in the etiology and pathogenesis of neurodegenerative diseases. Neurons...
4.
Beyer R, Fry R, Lasarev M, McConnachie L, Meira L, Palmer V, et al.
Toxicol Sci
. 2007 Jun;
99(1):326-37.
PMID: 17562736
Gene expression profiling is a widely used technique with data from the majority of published microarray studies being publicly available. These data are being used for meta-analyses and in silico...
5.
Powell C, Kosyk O, Ross P, Schoonhoven R, Boysen G, Swenberg J, et al.
Toxicol Sci
. 2006 Jun;
93(1):213-22.
PMID: 16751229
Toxicogenomics provides the ability to examine in greater detail the underlying molecular events that precede and accompany toxicity, thus allowing prediction of adverse events at much earlier times compared to...
6.
Powell C, Kosyk O, Bradford B, Parker J, Lobenhofer E, Denda A, et al.
Hepatology
. 2005 Oct;
42(5):1137-47.
PMID: 16250055
Hepatocellular carcinoma (HCC) is the terminal event in chronic liver diseases with repeated cycles of cellular injury and regeneration. Although much is known about the cellular pathogenesis and etiological agents...
7.
Powell C, Swenberg J, Rusyn I
Cancer Lett
. 2005 Sep;
229(1):1-11.
PMID: 16157213
Oxidative stress induced DNA damage is considered to be the most common insult affecting the genome. Moreover, it is recognized as a common pathway to mutations and is suggested to...
8.
McMillan D, Powell C, Bowman Z, Morrow J, Jollow D
Toxicol Sci
. 2005 Aug;
88(1):274-83.
PMID: 16107547
Lipid peroxidation and the accompanying translocation of phosphatidylserine (PS) from the inner to the outer leaflet of the lipid bilayer have recently been identified as key components of a signaling...
9.
Ruberu S, Liu Y, Wong C, Perera S, Langlois G, Doucette G, et al.
J AOAC Int
. 2003 Sep;
86(4):737-45.
PMID: 14509433
A receptor binding assay (RBA) for detection of paralytic shellfish poisoning (PSP) toxins was formatted for use in a high throughput detection system using microplate scintillation counting. The RBA technology...
10.
Baker T, Doucette G, Powell C, Boyer G, Plumley F
Toxicon
. 2003 Feb;
41(3):339-47.
PMID: 12565757
Saxitoxins, the etiological agent of paralytic shellfish poisoning, are synthesized by dinoflagellates and cyanobacteria. Several reports indicate that bacteria are capable of saxitoxin synthesis. Two bacterial strains were isolated from...