Christine Clayton
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Explore the profile of Christine Clayton including associated specialties, affiliations and a list of published articles.
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110
Citations
3378
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Recent Articles
1.
Waithaka A, Clayton C
BMC Res Notes
. 2022 Dec;
15(1):371.
PMID: 36528767
Objective: The cleavage and polyadenylation endonuclease CPSF73 is thought to be the target of the anti-trypanosomal benzoxaboroles AN7973, acoziborole and AN11736. We previously showed that AN7973 inhibits mRNA processing. We...
2.
Waithaka A, Maiakovska O, Grimm D, Melo Do Nascimento L, Clayton C
PLoS Negl Trop Dis
. 2022 Oct;
16(10):e0010876.
PMID: 36288402
Background: Spliced leader trans splicing is the addition of a short, capped sequence to the 5' end of mRNAs. It is widespread in eukaryotic evolution, but factors that influence trans...
3.
Bezerra M, Moura D, Freire E, Holetz F, Reis C, Monteiro T, et al.
Front Mol Biosci
. 2022 Oct;
9:971811.
PMID: 36275617
Gene expression in pathogenic protozoans of the family Trypanosomatidae has several novel features, including multiple eIF4F-like complexes involved in protein synthesis. The eukaryotic eIF4F complex, formed mainly by eIF4E and...
4.
Falk F, Melo Palhares R, Waithaka A, Clayton C
Mol Microbiol
. 2022 Sep;
118(4):457-476.
PMID: 36056730
Trypanosoma brucei has six versions of the cap-binding translation initiation factor EIF4E. We investigated the functions of EIF4E2, EIF4E3, EIF4E5, and EIF4E6 in bloodstream forms. We confirmed the protein associations...
5.
Liu B, Clayton C
BMC Res Notes
. 2022 Jul;
15(1):253.
PMID: 35841065
Objective: Trypanosoma brucei is a parasite of mammals and Tsetse flies, and control of mRNA stability is critical for parasite survival in the two different hosts. T. brucei RBP10 is...
6.
Bishola Tshitenge T, Clayton C
RNA
. 2022 Jul;
28(9):1239-1262.
PMID: 35793904
The parasite grows as bloodstream forms in mammals, and as procyclic forms in tsetse flies. Transcription is polycistronic, all mRNAs are spliced, and polyadenylation sites are defined by downstream splicing...
7.
Bishola Tshitenge T, Reichert L, Liu B, Clayton C
PLoS Negl Trop Dis
. 2022 Mar;
16(3):e0010030.
PMID: 35312693
The parasite Trypanosoma brucei grows as bloodstream forms in mammalian hosts, and as procyclic forms in tsetse flies. In trypanosomes, gene expression regulation depends heavily on post-transcriptional mechanisms. Both the...
8.
Bishola Tshitenge T, Clayton C
Parasitology
. 2022 Mar;
149(3):356-370.
PMID: 35264260
In Trypanosoma brucei and related Kinetoplastids, regulation of gene expression occurs mostly post-transcriptionally, and RNA-binding proteins play a critical role in the regulation of mRNA and protein abundance. Trypanosoma brucei...
9.
Falk F, Kamanyi Marucha K, Clayton C
PLoS One
. 2021 Nov;
16(11):e0258903.
PMID: 34807934
Most transcription in Trypanosoma brucei is constitutive and polycistronic. Consequently, the parasite relies on post-transcriptional mechanisms, especially affecting translation initiation and mRNA decay, to control gene expression both at steady-state...
10.
Mulindwa J, Ssentamu G, Matovu E, Kamanyi Marucha K, Aresta-Branco F, Helbig C, et al.
PLoS Negl Trop Dis
. 2021 Sep;
15(9):e0009738.
PMID: 34516555
Most researchers who study unicellular eukaryotes work with an extremely limited number of laboratory-adapted isolates that were obtained from the field decades ago, but the effects of passage in laboratory...