Simon Haile
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Explore the profile of Simon Haile including associated specialties, affiliations and a list of published articles.
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28
Citations
1141
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Recent Articles
1.
Haile S, Corbett R, ONeill K, Xu J, Smailus D, Pandoh P, et al.
Front Genet
. 2024 Dec;
15:1466338.
PMID: 39687742
The advent of long-read (LR) sequencing technologies has provided a direct opportunity to determine the structure of transcripts with potential for end-to-end sequencing of full-length RNAs. LR methods that have...
2.
Xu J, Pandoh P, Corbett R, Smailus D, Bowlby R, Brooks D, et al.
Biotechniques
. 2023 Aug;
75(2):47-55.
PMID: 37551834
High-throughput total nucleic acid (TNA) purification methods based on solid-phase reversible immobilization (SPRI) beads produce TNA suitable for both genomic and transcriptomic applications. Even so, small RNA species, including miRNA,...
3.
Haile S, Nikiforuk A, Pandoh P, Twa D, Smailus D, Nguyen J, et al.
J Virol Methods
. 2021 Oct;
299:114339.
PMID: 34687784
The COVID-19 pandemic has highlighted the need for generic reagents and flexible systems in diagnostic testing. Magnetic bead-based nucleic acid extraction protocols using 96-well plates on open liquid handlers are...
4.
Haile S, Corbett R, Leblanc V, Wei L, Pleasance S, Bilobram S, et al.
Front Genet
. 2021 Jun;
12:665888.
PMID: 34149808
RNA sequencing (RNAseq) has been widely used to generate bulk gene expression measurements collected from pools of cells. Only relatively recently have single-cell RNAseq (scRNAseq) methods provided opportunities for gene...
5.
Coope R, Schlosser C, Corbett R, Pleasance S, Tessier-Cloutier B, Pandoh P, et al.
J Pathol
. 2020 Nov;
253(2):225-233.
PMID: 33135777
The practical application of genome-scale technologies to precision oncology research requires flexible tissue processing strategies that can be used to differentially select both tumour and normal cell populations from formalin-fixed,...
6.
Haile S, Corbett R, Bilobram S, Mungall K, Grande B, Kirk H, et al.
PLoS One
. 2019 Nov;
14(10):e0224578.
PMID: 31671154
Next generation RNA-sequencing (RNA-seq) is a flexible approach that can be applied to a range of applications including global quantification of transcript expression, the characterization of RNA structure such as...
7.
Pandoh P, Corbett R, McDonald H, Alcaide M, Kirk H, Trinh E, et al.
Biotechniques
. 2019 Feb;
66(2):85-92.
PMID: 30744412
The analysis of cell-free circulating tumor DNA (ctDNA) is potentially a less invasive, more dynamic assessment of cancer progression and treatment response than characterizing solid tumor biopsies. Standard isolation methods...
8.
Haile S, Corbett R, Bilobram S, Bye M, Kirk H, Pandoh P, et al.
Nucleic Acids Res
. 2018 Nov;
47(2):e12.
PMID: 30418619
Tissues used in pathology laboratories are typically stored in the form of formalin-fixed, paraffin-embedded (FFPE) samples. One important consideration in repurposing FFPE material for next generation sequencing (NGS) analysis is...
9.
Haile S, Corbett R, MacLeod T, Bilobram S, Smailus D, Tsao P, et al.
BMC Genomics
. 2017 Jul;
18(1):515.
PMID: 28679365
Background: RNA-Sequencing (RNA-seq) is now commonly used to reveal quantitative spatiotemporal snapshots of the transcriptome, the structures of transcripts (splice variants and fusions) and landscapes of expressed mutations. However, standard...
10.
Haile S, Pandoh P, McDonald H, Corbett R, Tsao P, Kirk H, et al.
PLoS One
. 2017 Jun;
12(6):e0178706.
PMID: 28570594
Curation and storage of formalin-fixed, paraffin-embedded (FFPE) samples are standard procedures in hospital pathology laboratories around the world. Many thousands of such samples exist and could be used for next...