Christine Borner
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Explore the profile of Christine Borner including associated specialties, affiliations and a list of published articles.
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22
Citations
561
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Recent Articles
1.
Chiarlone A, Borner C, Martin-Gomez L, Jimenez-Gonzalez A, Garcia-Concejo A, Garcia-Bermejo M, et al.
Neuropharmacology
. 2016 May;
108:345-52.
PMID: 27179908
Cannabinoid CB1 receptor, the molecular target of endocannabinoids and cannabis active components, is one of the most abundant metabotropic receptors in the brain. Cannabis is widely used for both recreational...
2.
Borner C, Kraus J
J Immunol
. 2013 Sep;
191(9):4640-7.
PMID: 24068670
Opioids potently inhibit a number of physiological and pathophysiological effects such as pain and inflammation in the brain and the periphery. One of the targets of opioids mediating such effects...
3.
Borner C, Lanciotti S, Koch T, Hollt V, Kraus J
J Neuroimmunol
. 2013 Aug;
263(1-2):35-42.
PMID: 23965172
Opioids are irreplaceable for the treatment of severe pain. However, opioid-induced immunomodulation affects therapies. Here we report that treatment of human T lymphocytes with the opioids fentanyl, methadone, loperamide and...
4.
Borner C, Martella E, Hollt V, Kraus J
Neuroimmunomodulation
. 2012 Jan;
19(3):180-6.
PMID: 22262103
Objective: The aim of this study was to investigate the effect of the epigenetic modifiers trichostatin A and 5-aza-2'-deoxycytidine on the expression of the cannabinoid receptors CB1 and CB2 and...
5.
Borner C, Hollt V, Kraus J
Mol Pharmacol
. 2012 Jan;
81(4):587-97.
PMID: 22258905
Opioids potently modulate neuronal functions, for example, by regulating the activity of transcription factors. Here, we investigated the effect of morphine on the activity of the transcription factor nuclear factor...
6.
Blazquez C, Chiarlone A, Sagredo O, Aguado T, Pazos M, Resel E, et al.
Brain
. 2010 Oct;
134(Pt 1):119-36.
PMID: 20929960
Endocannabinoids act as neuromodulatory and neuroprotective cues by engaging type 1 cannabinoid receptors. These receptors are highly abundant in the basal ganglia and play a pivotal role in the control...
7.
Kraus J, Lehmann L, Borner C, Hollt V
Mol Immunol
. 2010 Sep;
48(1-3):257-63.
PMID: 20828825
Various immunomodulatory effects of opioids are mediated by mu opioid receptors. While in resting T lymphocytes their expression is repressed, mu opioid receptors are induced by interleukin-4 via the transcription...
8.
Borner C, Smida M, Hollt V, Schraven B, Kraus J
J Biol Chem
. 2009 Oct;
284(51):35450-60.
PMID: 19858202
The aim of this study was to characterize inhibitory mechanisms on T cell receptor signaling mediated by the cannabinoid receptors CB1 and CB2. Both receptors are coupled to G(i/o) proteins,...
9.
Borner C, Warnick B, Smida M, Hartig R, Lindquist J, Schraven B, et al.
J Immunol
. 2009 Jun;
183(2):882-9.
PMID: 19561113
Opioids are widely used for the treatment of severe pain. However, it is also known that opioids, in particular morphine, cause immunosuppression. Therefore, their use may complicate treatment of persons...
10.
Koch T, Seifert A, Wu D, Rankovic M, Kraus J, Borner C, et al.
J Neurochem
. 2009 Jun;
110(4):1288-96.
PMID: 19519662
We have recently shown that the activation of the rat mu-opioid receptor (MOPr, also termed MOR1) by the mu-agonist [D-Ala(2), Me Phe(4), Glyol(5)]enkephalin (DAMGO) leads to an increase in phospholipase...