Michal Smida
Overview
Explore the profile of Michal Smida including associated specialties, affiliations and a list of published articles.
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24
Citations
448
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Recent Articles
1.
Moyano P, Kubina T, Paruch S, Jaroskova A, Novotny J, Skockova V, et al.
Angew Chem Int Ed Engl
. 2024 Nov;
64(1):e202412786.
PMID: 39503260
Protein kinases are key regulators of numerous biological processes and aberrant kinase activity can cause various diseases, particularly cancer. Herein, we report the identification of new series of highly selective...
2.
Stika J, Pesova M, Stano Kozubik K, Skalnikova M, Dostalova L, Loja T, et al.
Br J Haematol
. 2024 Aug;
205(6):2450-2458.
PMID: 39191490
The CYCS gene is highly evolutionarily conserved, with only a few pathogenic variants that cause thrombocytopenia-4 (THC4). Here, we report a novel CYCS variant NM_018947.6: c.59C>T [NP_061820.1:p.(Thr20Ile)] segregating with thrombocytopenia...
3.
Bobrowicz M, Kusowska A, Krawczyk M, Zhylko A, Forcados C, Slusarczyk A, et al.
Oncoimmunology
. 2024 Jun;
13(1):2362454.
PMID: 38846084
Rituximab (RTX) plus chemotherapy (R-CHOP) applied as a first-line therapy for lymphoma leads to a relapse in approximately 40% of the patients. Therefore, novel approaches to treat aggressive lymphomas are...
4.
Dave Z, Vondalova Blanarova O, cada S, Janovska P, Zezula N, Behal M, et al.
Front Cell Dev Biol
. 2022 Mar;
10:838871.
PMID: 35295854
Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are malignancies characterized by the dependence on B-cell receptor (BCR) signaling and by the high expression of ROR1, the cell surface...
5.
Skalnikova M, Stano Kozubik K, Trizuljak J, Vrzalova Z, Radova L, Reblova K, et al.
Int J Mol Sci
. 2022 Jan;
23(2).
PMID: 35055070
Bernard-Soulier syndrome (BSS) is a rare inherited disorder characterized by unusually large platelets, low platelet count, and prolonged bleeding time. BSS is usually inherited in an autosomal recessive (AR) mode...
6.
Ledererova A, Dostalova L, Kozlova V, Peschelova H, Ladungova A, Culen M, et al.
J Immunother Cancer
. 2021 Aug;
9(8).
PMID: 34413165
Background: Anti-CD19 chimeric antigen receptor T cells (CART-19) frequently induce remissions in hemato-oncological patients with recurred and/or refractory B-cell tumors. However, malignant cells sometimes escape the immunotherapeutic targeting by gene...
7.
Mancikova V, Smida M
Int J Mol Sci
. 2021 Jun;
22(11).
PMID: 34073911
Chimeric antigen receptor (CAR) T-cell therapy has already achieved remarkable remissions in some difficult-to-treat patients with B-cell malignancies. Although the clinical experience in chronic lymphocytic leukemia (CLL) patients is limited,...
8.
Stano Kozubik K, Radova L, Reblova K, Smida M, Zaliova Kubricanova M, Baloun J, et al.
Platelets
. 2020 Aug;
32(6):838-841.
PMID: 32819174
Germline mutations in gene cause inherited thrombocytopenia with leukemia predisposition. Here, we report on functional validation of W380R mutation segregating with thrombocytopenia in a family where two family members also...
9.
Mancikova V, Peschelova H, Kozlova V, Ledererova A, Ladungova A, Verner J, et al.
J Immunother Cancer
. 2020 Mar;
8(1).
PMID: 32217767
Background: While achieving prolonged remissions in other B cell-derived malignancies, chimeric antigen receptor (CAR) T cells still underperform when injected into patients with chronic lymphocytic leukemia (CLL). We studied the...
10.
Kozlova V, Ledererova A, Ladungova A, Peschelova H, Janovska P, Slusarczyk A, et al.
PLoS One
. 2020 Mar;
15(3):e0229170.
PMID: 32210425
Surface protein CD20 serves as the critical target of immunotherapy in various B-cell malignancies for decades, however its biological function and regulation remain largely elusive. Better understanding of CD20 function...