Christina J Crump
Overview
Explore the profile of Christina J Crump including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
292
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Crump C, Murrey H, Ballard T, Am Ende C, Wu X, Gertsik N, et al.
ACS Chem Neurosci
. 2016 Jun;
7(8):1166-73.
PMID: 27253220
γ-Secretase is a multiprotein complex that catalyzes intramembrane proteolysis associated with Alzheimer's disease and cancer. Here, we have developed potent sulfonamide clickable photoaffinity probes that target γ-secretase in vitro and...
2.
Crump C, Johnson D, Li Y
Biochemistry
. 2013 Apr;
52(19):3197-216.
PMID: 23614767
γ-Secretase is an aspartyl intramembranal protease composed of presenilin, Nicastrin, Aph1, and Pen2 with 19 transmembrane domains. γ-Secretase cleaves the amyloid precursor proteins (APP) to release Aβ peptides that likely...
3.
Pozdnyakov N, Murrey H, Crump C, Pettersson M, Ballard T, Am Ende C, et al.
J Biol Chem
. 2013 Feb;
288(14):9710-9720.
PMID: 23396974
γ-Secretase is an intramembrane aspartyl protease that cleaves the amyloid precursor protein to produce neurotoxic β-amyloid peptides (i.e. Aβ42) that have been implicated in the pathogenesis of Alzheimer disease. Small...
4.
Crump C, Castro S, Wang F, Pozdnyakov N, Ballard T, Sisodia S, et al.
Biochemistry
. 2012 Aug;
51(37):7209-11.
PMID: 22931393
The "Notch-sparing" γ-secretase inhibitor (GSI) BMS-708,163 (Avagacestat) is currently in phase II clinical trials for Alzheimer's disease. Unlike previously failed GSIs, BMS-708,163 is considered to be a promising drug candidate...
5.
Chau D, Crump C, Villa J, Scheinberg D, Li Y
J Biol Chem
. 2012 Mar;
287(21):17288-17296.
PMID: 22461631
Presenilin-1 (PS1) is the catalytic subunit of γ-secretase, and mutations in this protein cause familial Alzheimer Disease (FAD). However, little is known about how these mutations affect the active site...
6.
Crump C, Am Ende C, Ballard T, Pozdnyakov N, Pettersson M, Chau D, et al.
Bioorg Med Chem Lett
. 2012 Mar;
22(8):2997-3000.
PMID: 22418280
We have developed clickable active site-directed photoaffinity probes for γ-secretase which incorporate a photoreactive benzophenone group and an alkyne handle for subsequent click chemistry mediated conjugation with azide-linked reporter tags...
7.
Crump C, Fish B, Castro S, Chau D, Gertsik N, Ahn K, et al.
ACS Chem Neurosci
. 2012 Jan;
2(12):705-710.
PMID: 22229075
Aβ42 is believed to play a causative role in Alzheimer's disease (AD) pathogenesis. γ-Secretase modulators (GSMs) are actively being pursued as potential AD therapeutics because they selectively alter the cleavage...
8.
9.
Tian Y, Crump C, Li Y
J Biol Chem
. 2010 Aug;
285(42):32549-56.
PMID: 20675367
Processing of the amyloid precursor protein (APP) by β- and γ-secretases generates pathogenic β-amyloid (Aβ) peptides associated with Alzheimer disease (AD), whereas cleavage of APP by α-secretases precludes Aβ formation....