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» Authors » Christina A Gewinner

Christina A Gewinner

Explore the profile of Christina A Gewinner including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 76
Followers 0
Related Specialties
Cell Biology
Molecular Biology
Oncology
Top 10 Co-Authors
Lewis C Cantley
John M Asara
Janos Kriston-Vizi
John A Hartley
Krisna Prak
Takehiko Sasaki
Jared L Johnson
Ruth Jacobs
Felipe Cia Viciano
A W Edith Chan
Published In
Sci Signal
Mol Biol Cell
Oncotarget
Front Cell Dev Biol
Nat Struct Mol Biol
Affiliations
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Recent Articles
1.
Functional assessment of glucocerebrosidase modulator efficacy in primary patient-derived macrophages is essential for drug development and patient stratification
Welsh N, Gewinner C, Mistry K, Koglin M, Cooke J, Butler M, et al.
Haematologica . 2019 Sep; 105(5):e206-e209. PMID: 31558665
No abstract available.
2.
Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells
Pengo N, Prak K, Costa J, Luft C, Agrotis A, Freeman J, et al.
Front Cell Dev Biol . 2018 Nov; 6:148. PMID: 30443548
Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system required for autophagosome formation, maturation and closure. Members of the ATG4 and the LC3/GABARAP family have been implicated...
3.
Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype
Alli-Balogun G, Gewinner C, Jacobs R, Kriston-Vizi J, Waugh M, Minogue S
Mol Biol Cell . 2016 Nov; 27(25):4033-4042. PMID: 27798239
The type II phosphatidylinositol 4-kinase (PI4KII) enzymes synthesize the lipid phosphatidylinositol 4-phosphate (PI(4)P), which has been detected at the Golgi complex and endosomal compartments and recruits clathrin adaptors. Despite common...
4.
EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src
Begley M, Yun C, Gewinner C, Asara J, Johnson J, Coyle A, et al.
Nat Struct Mol Biol . 2015 Nov; 22(12):983-90. PMID: 26551075
Aberrant activation of the EGF receptor (EGFR) contributes to many human cancers by activating the Ras-MAPK pathway and other pathways. EGFR signaling is augmented by Src-family kinases, but the mechanism...
5.
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment
Ip L, Poulogiannis G, Viciano F, Sasaki J, Kofuji S, Spanswick V, et al.
Oncotarget . 2015 Apr; 6(12):10548-62. PMID: 25868852
Treatment options for ovarian cancer patients remain limited and overall survival is less than 50% despite recent clinical advances. The lipid phosphatase inositol polyphosphate 4-phosphatase type II (INPP4B) has been...
6.
Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases
Chen S, Jiang X, Gewinner C, Asara J, Simon N, Cai C, et al.
Sci Signal . 2013 May; 6(277):ra40. PMID: 23716717
The nonreceptor tyrosine kinase BMX (bone marrow tyrosine kinase gene on chromosome X) is abundant in various cell types and activated downstream of phosphatidylinositol-3 kinase (PI3K) and the kinase Src,...