The Impact of Plasmodium-driven Immunoregulatory Networks on Immunity to Malaria

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2024 Jun 11

PMID 38862638

Authors

Michelle J Boyle

Christian R Engwerda

Prasanna Jagannathan

Affiliations

Soon will be listed here.

Abstract

Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory responses across the immune landscape. These regulatory responses help to protect against inflammatory disease but may in some situations hamper the acquisition of adaptive immune responses that clear parasites. In addition, the regulatory responses that occur during Plasmodium infection may negatively affect malaria vaccine efficacy in the most at-risk populations. Here, we discuss the specific cellular mechanisms of immunoregulatory networks that develop during malaria, with a focus on knowledge gained from human studies and studies that involve the main malaria parasite to affect humans, Plasmodium falciparum. Leveraging this knowledge may lead to the development of new therapeutic approaches to increase protective immunity to malaria during infection or after vaccination.

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