Christian Mandrycky
Overview
Explore the profile of Christian Mandrycky including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
571
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Recent Articles
1.
Mohran S, McMillen T, Mandrycky C, Tu A, Kooiker K, Qian W, et al.
J Gen Physiol
. 2024 Sep;
156(11).
PMID: 39302315
Sarcomere activation in striated muscle requires both thin filament-based and thick filament-based activation mechanisms. Recent studies have shown that myosin heads on the thick filaments undergo OFF to ON structural...
2.
Turner K, Vander Top B, Kooiker K, Mohran S, Mandrycky C, McMillen T, et al.
J Physiol
. 2024 Sep;
602(19):4941-4958.
PMID: 39283968
Precise regulation of sarcomeric contraction is essential for normal cardiac function. The heart must generate sufficient force to pump blood throughout the body, but either inadequate or excessive force can...
3.
Mandrycky C, Ishida T, Rayner S, Heck A, Hadland B, Zheng Y
bioRxiv
. 2024 Jun;
PMID: 38854073
Blood flow within the vasculature is a critical determinant of endothelial cell (EC) identity and functionality, yet the intricate interplay of various hemodynamic forces and their collective impact on endothelial...
4.
Mohran S, Kooiker K, Mahoney-Schaefer M, Mandrycky C, Kao K, Tu A, et al.
J Biol Chem
. 2023 Dec;
300(1):105565.
PMID: 38103642
The biochemical SRX (super-relaxed) state of myosin has been defined as a low ATPase activity state. This state can conserve energy when the myosin is not recruited for muscle contraction....
5.
Mohran S, Steczina S, Mandrycky C, Kao K, Regnier M
Methods Mol Biol
. 2023 Dec;
2735:213-233.
PMID: 38038851
Isolated myofibrils provide biomechanical data at the contractile organelle level that are independent of cellular calcium handling and signaling pathways. These myofibrils can be harvested from animal tissue, human muscle...
6.
Kooiker K, Mohran S, Turner K, Ma W, Martinson A, Flint G, et al.
Circ Res
. 2023 Jul;
133(5):430-443.
PMID: 37470183
Background: Modulating myosin function is a novel therapeutic approach in patients with cardiomyopathy. Danicamtiv is a novel myosin activator with promising preclinical data that is currently in clinical trials. While...
7.
Kooiker K, Mohran S, Turner K, Ma W, Flint G, Qi L, et al.
bioRxiv
. 2023 Feb;
PMID: 36778318
Significance Statement: Directly augmenting sarcomere function has potential to overcome limitations of currently used inotropic agents to improve cardiac contractility. Myosin modulation is a novel mechanism for increased contraction in...
8.
Mandrycky C, Hadland B, Zheng Y
Sci Adv
. 2020 Sep;
6(38).
PMID: 32938662
Vascularization remains a long-standing challenge in engineering complex tissues. Particularly needed is recapitulating 3D vascular features, including continuous geometries with defined diameter, curvature, and torsion. Here, we developed a spiral...
9.
Levitt M, Mandrycky C, Abel A, Kelly C, Levy S, Chivukula V, et al.
J Neurointerv Surg
. 2019 Apr;
11(10):999-1003.
PMID: 30979845
Objectives: To study the correlation between wall shear stress and endothelial cell expression in a patient-specific, three-dimensional (3D)-printed model of a cerebral aneurysm. Materials And Methods: A 3D-printed model of...
10.
Mandrycky C, Phong K, Zheng Y
MRS Commun
. 2018 May;
7(3):332-347.
PMID: 29750131
Tissue engineering has been recognized as a translational approach to replace damaged tissue or whole organs. Engineering tissue, however, faces an outstanding knowledge gap in the challenge to fully recapitulate...