Christian J Leumann
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Explore the profile of Christian J Leumann including associated specialties, affiliations and a list of published articles.
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94
Citations
666
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Recent Articles
1.
Leumann C
Chimia (Aarau)
. 2024 Sep;
78(9):610-612.
PMID: 39323195
Scientific integrity is the most important aspect that higher education institutions have to take care of, as it conveys credibility and acceptance of science to the public. Although science has...
2.
Evequoz D, Verhaart I, van de Vijver D, Renner W, Aartsma-Rus A, Leumann C
Nucleic Acids Res
. 2021 Dec;
49(21):12089-12105.
PMID: 34850138
Antisense oligonucleotides are small pieces of modified DNA or RNA, which offer therapeutic potential for many diseases. We report on the synthesis of 7',5'-α-bc-DNA phosphoramidite building blocks, bearing the A,...
3.
Rothlisberger P, Levi-Acobas F, Leumann C, Hollenstein M
Bioorg Med Chem
. 2020 Apr;
28(11):115487.
PMID: 32284226
The incorporation of nucleotides equipped with C-glycosidic aromatic nucleobases into DNA and RNA is an alluring strategy for a number of practical applications including fluorescent labelling of oligonucleotides, expansion of...
4.
Levi-Acobas F, Katolik A, Rothlisberger P, Cokelaer T, Sarac I, Damha M, et al.
Org Biomol Chem
. 2019 Aug;
17(35):8083-8087.
PMID: 31460550
A modified nucleoside triphosphate bearing two modifications based on a 2'-deoxy-2'-fluoro-arabinofuranose sugar and a uracil nucleobase equipped with a C5-ethynyl moiety (5-ethynyl-2'F-ANA UTP) was synthesized. This nucleotide analog could enzymatically...
5.
Diafa S, Evequoz D, Leumann C, Hollenstein M
Methods Mol Biol
. 2019 Apr;
1973:1-13.
PMID: 31016692
Chemical modification of nucleic acids can be achieved by the enzymatic polymerization of modified nucleoside triphosphates (dN*TPs). This approach obviates some of the requirements and drawbacks imposed by the more...
6.
Istrate A, Johannsen S, Istrate A, Sigel R, Leumann C
Nucleic Acids Res
. 2019 Mar;
47(9):4872-4882.
PMID: 30916334
Tc-DNA is a conformationally constrained oligonucleotide analogue which shows significant increase in thermal stability when hybridized with RNA, DNA or tc-DNA. Remarkably, recent studies revealed that tc-DNA antisense oligonucleotides (AO)...
7.
Frei S, Katolik A, Leumann C
Beilstein J Org Chem
. 2019 Jan;
15:79-88.
PMID: 30680042
Here we present the synthesis, the biophysical properties, and the RNase H profile of 6'-difluorinated [4.3.0]bicyclo-DNA (6'-diF-bc-DNA). The difluorinated thymidine phosphoramidite building block was synthesized starting from an already known...
8.
Frei S, Istrate A, Leumann C
Beilstein J Org Chem
. 2019 Jan;
14:3088-3097.
PMID: 30643586
Here we report on the synthesis, biophysical properties and molecular modeling of oligonucleotides containing unsaturated 6'-fluoro[4.3.0]bicyclo nucleotides (6'F-bc-DNA). Two 6'F-bc phosphoramidite building blocks (T and C) were synthesized starting from...
9.
Hari Y, Leumann C, Schurch S
J Am Soc Mass Spectrom
. 2017 Sep;
28(12):2677-2685.
PMID: 28932996
Radical activation methods, such as electron transfer dissociation (ETD), produce structural information complementary to collision-induced dissociation. Herein, electron transfer dissociation of 3-fold protonated DNA hexamers was studied to gain insight...
10.
Robin V, Griffith G, Carter J, Leumann C, Garcia L, Goyenvalle A
Mol Ther Nucleic Acids
. 2017 Jun;
7:81-89.
PMID: 28624227
Spinal muscular atrophy (SMA) is a recessive disease caused by mutations in the SMN1 gene, which encodes the protein survival motor neuron (SMN), whose absence dramatically affects the survival of...