Christian C Lee
Overview
Explore the profile of Christian C Lee including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
748
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Recent Articles
1.
Thoma G, Veenstra S, Strang R, Blanz J, Vangrevelinghe E, Berghausen J, et al.
Bioorg Med Chem Lett
. 2015 Sep;
25(20):4642-7.
PMID: 26320624
Design and optimization of benzo- and pyrido-thiazoles/isothiazoles are reported leading to the discovery of the potent, orally bioavailable Syk inhibitor 5, which was found to be active in a rat...
2.
Thoma G, Smith A, van Eis M, Vangrevelinghe E, Blanz J, Aichholz R, et al.
J Med Chem
. 2015 Jan;
58(4):1950-63.
PMID: 25633741
We describe the discovery of selective and potent Syk inhibitor 11, which exhibited favorable PK profiles in rat and dog and was found to be active in a collagen-induced arthritis...
3.
Thoma G, Blanz J, Buhlmayer P, Druckes P, Kittelmann M, Smith A, et al.
Bioorg Med Chem Lett
. 2014 Apr;
24(10):2278-82.
PMID: 24726806
We describe two series of Syk inhibitors which potently abrogate Syk kinase function in enzymatic assays, cellular assays and in primary cells in the presence of blood. Introduction of a...
4.
Karabencheva T, Lee C, Black G, Donev R, Christov C
Mol Biosyst
. 2014 Mar;
10(6):1490-5.
PMID: 24675991
Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type...
5.
Friboulet L, Li N, Katayama R, Lee C, Gainor J, Crystal A, et al.
Cancer Discov
. 2014 Mar;
4(6):662-673.
PMID: 24675041
Unlabelled: Non-small cell lung cancers (NSCLC) harboring anaplastic lymphoma kinase (ALK) gene rearrangements invariably develop resistance to the ALK tyrosine kinase inhibitor (TKI) crizotinib. Herein, we report the first preclinical...
6.
Marsilje T, Pei W, Chen B, Lu W, Uno T, Jin Y, et al.
J Med Chem
. 2013 Jun;
56(14):5675-90.
PMID: 23742252
The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor 15b (LDK378) are described. In this initial report, preliminary...
7.
Lee C, Jia Y, Li N, Sun X, Ng K, Ambing E, et al.
Biochem J
. 2010 Jul;
430(3):425-37.
PMID: 20632993
ALK (anaplastic lymphoma kinase) is an RTK (receptor tyrosine kinase) of the IRK (insulin receptor kinase) superfamily, which share an YXXXYY autophosphorylation motif within their A-loops (activation loops). A common...
8.
Zhang X, Bursulaya B, Lee C, Chen B, Pivaroff K, Jegla T
Biophys J
. 2009 Jul;
97(1):110-20.
PMID: 19580749
Voltage-gated K+ channels share a common voltage sensor domain (VSD) consisting of four transmembrane helices, including a highly mobile S4 helix that contains the major gating charges. Activation of ether-a-go-go...
9.
Barouch-Bentov R, Che J, Lee C, Yang Y, Herman A, Jia Y, et al.
Mol Cell
. 2009 Jan;
33(1):43-52.
PMID: 19150426
The glycine-rich G loop controls ATP binding and phosphate transfer in protein kinases. Here we show that the functions of Src family and Abl protein tyrosine kinases require an electrostatic...
10.
Lee C, Adamson D, Madani M, Manecke Jr G
J Cardiothorac Vasc Anesth
. 2006 Aug;
20(4):562-4.
PMID: 16884989
No abstract available.