Chris Hague
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Explore the profile of Chris Hague including associated specialties, affiliations and a list of published articles.
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28
Citations
787
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Recent Articles
1.
Lee K, Navaluna E, Marsh N, Janezic E, Hague C
SLAS Discov
. 2021 Jan;
26(4):570-578.
PMID: 33402011
We have developed a novel reporter assay that leverages SNAP-epitope tag/near-infrared (NIR) imaging technology to monitor G protein-coupled receptor (GPCR) degradation in human cell lines. N-terminal SNAP-tagged GPCRs were subcloned...
2.
Janezic E, Lauer S, Williams R, Chungyoun M, Lee K, Navaluna E, et al.
Sci Rep
. 2020 May;
10(1):7209.
PMID: 32350295
G protein-coupled receptor (GPCR) biogenesis, trafficking, and function are regulated by post-translational modifications, including N-glycosylation of asparagine residues. α-adrenergic receptors (α-ARs) - key regulators of central and autonomic nervous system...
3.
Lee B, Bussi I, de la Iglesia H, Hague C, Koh D, Hille B
J Pineal Res
. 2019 Nov;
68(2):e12622.
PMID: 31715643
Introduction: At night, the pineal gland produces the indoleamines, melatonin, N-acetylserotonin (NAS), and N-acetyltryptamine (NAT). Melatonin is accepted as a hormone of night. Could NAS and NAT serve that role...
4.
Janezic E, Harris D, Dinh D, Lee K, Stewart A, Hinds T, et al.
Sci Rep
. 2019 Oct;
9(1):14073.
PMID: 31575922
Many G protein-coupled receptors (GPCRs) are organized as dynamic macromolecular complexes in human cells. Unraveling the structural determinants of unique GPCR complexes may identify unique protein:protein interfaces to be exploited...
5.
Harris D, Park J, Lee K, Xu C, Stella N, Hague C
J Pharmacol Exp Ther
. 2017 Feb;
361(2):219-228.
PMID: 28196836
Small molecules that target the adrenergic family of G protein-coupled receptors (GPCRs) show promising therapeutic efficacy for the treatment of various cancers. In this study, we report that human colon...
6.
Kountz T, Lee K, Aggarwal-Howarth S, Curran E, Park J, Harris D, et al.
J Biol Chem
. 2016 Jul;
291(35):18210-21.
PMID: 27382054
The α1D-adrenergic receptor (ADRA1D) is a key regulator of cardiovascular, prostate, and central nervous system functions. This clinically relevant G protein-coupled receptor has proven difficult to study, as it must...
7.
Camp N, Lee K, Cherry A, Wacker-Mhyre J, Kountz T, Park J, et al.
Pharmacol Res
. 2016 Jan;
105:13-21.
PMID: 26773201
G protein-coupled receptors (GPCRs) are essential membrane proteins that facilitate cell-to-cell communication and co-ordinate physiological processes. At least 30 human GPCRs contain a Type I PSD-95/DLG/Zo-1 (PDZ) ligand in their...
8.
Camp N, Lee K, Wacker-Mhyre J, Kountz T, Park J, Harris D, et al.
Cell Discov
. 2015 Dec;
1.
PMID: 26617989
Recent advances in proteomic technology reveal G-protein-coupled receptors (GPCRs) are organized as large, macromolecular protein complexes in cell membranes, adding a new layer of intricacy to GPCR signaling. We previously...
9.
Lyssand J, Lee K, DeFino M, Adams M, Hague C
Biochem Biophys Res Commun
. 2011 Aug;
412(4):596-601.
PMID: 21846462
α(1D)-Adrenergic receptors, key regulators of cardiovascular system function, are organized as a multi-protein complex in the plasma membrane. Using a Type-I PDZ-binding motif in their distal C-terminal domain, α(1D)-ARs associate...
10.
Olson V, Rockett H, Reh R, Redila V, Tran P, Venkov H, et al.
Biol Psychiatry
. 2011 Jan;
70(5):441-8.
PMID: 21251647
Background: Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder precipitated by exposure to extreme traumatic stress. Yet, most individuals exposed to traumatic stress do not develop PTSD and may...