Chris Hague
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Explore the profile of Chris Hague including associated specialties, affiliations and a list of published articles.
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28
Citations
787
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Recent Articles
11.
Lyssand J, Whiting J, Lee K, Kastl R, Wacker J, Bruchas M, et al.
Proc Natl Acad Sci U S A
. 2010 Dec;
107(50):21854-9.
PMID: 21115837
α(1D)-Adrenergic receptors (ARs) are key regulators of cardiovascular system function that increase blood pressure and promote vascular remodeling. Unfortunately, little information exists about the signaling pathways used by this important...
12.
DeFino M, Wacker J, Lyssand J, Wang E, Hague C
Biochem Biophys Res Commun
. 2010 Feb;
393(4):603-8.
PMID: 20152817
Precise spatial and temporal expression of the recently identified G-protein coupled receptor GPR54 is critical for proper reproductive function and metastasis suppression. However, regulatory factors that control GPR54 expression remain...
13.
Jensen J, Lyssand J, Hague C, Hille B
J Gen Physiol
. 2009 Apr;
133(4):347-59.
PMID: 19332618
G protein-coupled receptors initiate signaling cascades. M(1) muscarinic receptor (M(1)R) activation couples through Galpha(q) to stimulate phospholipase C (PLC), which cleaves phosphatidylinositol 4,5-bisphosphate (PIP(2)). Depletion of PIP(2) closes PIP(2)-requiring Kv7.2/7.3...
14.
Wacker J, Feller D, Tang X, DeFino M, Namkung Y, Lyssand J, et al.
J Biol Chem
. 2008 Sep;
283(45):31068-78.
PMID: 18772143
The G-protein-coupled receptor (GPCR) GPR54 is essential for the development and maintenance of reproductive function in mammals. A point mutation (L148S) in the second intracellular loop (IL2) of GPR54 causes...
15.
Lyssand J, DeFino M, Tang X, Hertz A, Feller D, Wacker J, et al.
J Biol Chem
. 2008 May;
283(27):18792-800.
PMID: 18468998
Hypertension is a cardiovascular disease associated with increased plasma catecholamines, overactivation of the sympathetic nervous system, and increased vascular tone and total peripheral resistance. A key regulator of sympathetic nervous...
16.
Chen Z, Hague C, Hall R, Minneman K
J Biol Chem
. 2006 Mar;
281(18):12414-20.
PMID: 16533813
To find novel cytoplasmic binding partners of the alpha1D-adrenergic receptor (AR), a yeast two-hybrid screen using the alpha1D-AR C terminus as bait was performed on a human brain cDNA library....
17.
Hague C, Lee S, Chen Z, Prinster S, Hall R, Minneman K
Mol Pharmacol
. 2005 Oct;
69(1):45-55.
PMID: 16195468
Heterologous expression of alpha(1D)-adrenergic receptors (alpha(1D)-ARs) in most cell types results in intracellular retention and little or no functionality. We showed previously that heterodimerization with alpha(1B)-ARs promotes surface localization of...
18.
Prinster S, Hague C, Hall R
Pharmacol Rev
. 2005 Aug;
57(3):289-98.
PMID: 16109836
G protein-coupled receptors (GPCRs) are cell surface receptors that mediate physiological responses to a diverse array of stimuli. GPCRs have traditionally been thought to act as monomers, but recent evidence...
19.
Hague C, Bernstein L, Ramineni S, Chen Z, Minneman K, Hepler J
J Biol Chem
. 2005 May;
280(29):27289-95.
PMID: 15917235
Regulators of G-protein signaling (RGS) proteins act directly on Galpha subunits to increase the rate of GTP hydrolysis and to terminate signaling. However, the mechanisms involved in determining their specificities...
20.
Hague C, Hall R, Minneman K
Mol Interv
. 2004 Dec;
4(6):321-2.
PMID: 15616160
Research on olfaction has been fraught with considerable frustration because none of the hundreds of olfactory receptors make it to the cell surface on their own when expressed in heterologous...