Choonkeun Kim
Overview
Explore the profile of Choonkeun Kim including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
16
Citations
533
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0
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Recent Articles
1.
Dik D, Madukoma C, Tomoshige S, Kim C, Lastochkin E, Boggess W, et al.
ACS Chem Biol
. 2019 Jan;
14(2):296-303.
PMID: 30620575
The interplay between the activities of lytic transglycosylases (LTs) and penicillin-binding proteins (PBPs) is critical for the health of the bacterial cell wall. Bulgecin A (a natural-product inhibitor of LTs)...
2.
Dordel J, Kim C, Chung M, Pardos de la Gandara M, Holden M, Parkhill J, et al.
mBio
. 2014 Apr;
5(2):e01000.
PMID: 24713324
We identified mutated genes in highly resistant subpopulations of methicillin-resistant Staphylococcus aureus (MRSA) that are most likely responsible for the historic failure of the β-lactam family of antibiotics as therapeutic...
3.
Kim C, Mwangi M, Chung M, Milheirico C, Milheirco C, de Lencastre H, et al.
PLoS One
. 2013 Dec;
8(12):e82814.
PMID: 24349368
All methicillin resistant S. aureus (MRSA) strains carry an acquired genetic determinant--mecA or mecC--which encode for a low affinity penicillin binding protein -PBP2A or PBP2A'--that can continue the catalysis of...
4.
Mwangi M, Kim C, Chung M, Tsai J, Vijayadamodar G, Benitez M, et al.
Microb Drug Resist
. 2013 May;
19(3):153-9.
PMID: 23659600
The overwhelming majority of methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates exhibit a peculiar heterogeneous resistance to β-lactam antibiotics: in cultures of such strains, the majority of cells display only a...
5.
Kim C, Milheirico C, Gardete S, Holmes M, Holden M, de Lencastre H, et al.
J Biol Chem
. 2012 Sep;
287(44):36854-63.
PMID: 22977239
Methicillin-resistant Staphylococcus aureus (MRSA) strains show strain-to-strain variation in resistance level, in genetic background, and also in the structure of the chromosomal cassette (SCCmec) that carries the resistance gene mecA....
6.
Gardete S, Kim C, Hartmann B, Mwangi M, Roux C, Dunman P, et al.
PLoS Pathog
. 2012 Feb;
8(2):e1002505.
PMID: 22319446
An isolate of the methicillin-resistant Staphylococcus aureus (MRSA) clone USA300 with reduced susceptibility to vancomycin (SG-R) (i.e, vancomycin-intermediate S. aureus, VISA) and its susceptible "parental" strain (SG-S) were recovered from...
7.
Chung M, Antignac A, Kim C, Tomasz A
Antimicrob Agents Chemother
. 2008 May;
52(8):2709-17.
PMID: 18505853
Multidrug-resistant strains of Staphylococcus aureus continue to increase in frequency worldwide, both in hospitals and in the community, raising serious problems for the chemotherapy of staphylococcal disease. Ceftobiprole (BPR; BAL9141),...
8.
Toth M, Zajicek J, Kim C, Chow J, Smith C, Mobashery S, et al.
Biochemistry
. 2007 Apr;
46(18):5570-8.
PMID: 17425289
The major mechanism of resistance to aminoglycosides in clinical bacterial isolates is the covalent modification of these antibiotics by enzymes produced by the bacteria. Aminoglycoside 2''-Ib phosphotransferase [APH(2'')-Ib] produces resistance...
9.
Kim C, Villegas-Estrada A, Hesek D, Mobashery S
Biochemistry
. 2007 Apr;
46(17):5270-82.
PMID: 17417880
A recently discovered bifunctional antibiotic-resistance enzyme named AAC(3)-Ib/AAC(6')-Ib', from Pseudomonas aeruginosa, catalyzes acetylation of aminoglycoside antibiotics. Since both domains are acetyltransferases, each was cloned and purified for mechanistic studies. The...
10.
Kim C, Hesek D, Zajicek J, Vakulenko S, Mobashery S
Biochemistry
. 2006 Jul;
45(27):8368-77.
PMID: 16819836
A newly discovered bifunctional antibiotic resistance enzyme from Serratia marcescens catalyzes adenylation and acetylation of aminoglycoside antibiotics. The structure assignment of the enzymic products indicated that acetylation takes place on...