Cho Tang
Overview
Explore the profile of Cho Tang including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
934
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Recent Articles
1.
Jiao G, Cregar L, Wang J, Millis S, Tang C, OMalley S, et al.
Proc Natl Acad Sci U S A
. 2006 Dec;
103(52):19707-12.
PMID: 17179036
Furin plays a crucial role in embryogenesis and homeostasis and in diseases such as Alzheimer's disease, cancer, and viral and bacterial infections. Thus, inhibition of furin may provide a feasible...
2.
Jiao G, Simo O, Nagata M, OMalley S, Hemscheidt T, Cregar L, et al.
Bioorg Med Chem Lett
. 2006 Jul;
16(19):5183-9.
PMID: 16870442
A series of mono-, di-, and tri-guanidinylated derivatives of neamine were prepared via selective guanidinylation of neamine. These molecules represent a novel scaffold as inhibitors of anthrax lethal factor zinc...
3.
Jiao G, Cregar L, Goldman M, Millis S, Tang C
Bioorg Med Chem Lett
. 2006 Jan;
16(6):1527-31.
PMID: 16386899
Anthrax lethal factor is a Zn(2+)-dependent metalloprotease and the key virulence factor of tripartite anthrax toxin secreted by Bacillus anthracis, the causative agent of anthrax. A series of guanidinylated 2,5-dideoxystreptamine...
4.
Guan H, Laird A, Blake R, Tang C, Liang C
Bioorg Med Chem Lett
. 2003 Dec;
14(1):187-90.
PMID: 14684325
A novel series of substituted 3-[3-(aminopropyl)-4,5,6,7-tetrahydro-1H-indol-2-ylmethylene]-1,3-dihydro-indole-2-ones was discovered as potent inhibitors of the non-receptor tyrosine kinase Src and Yes. A structure-activity relationship was developed in order to optimize their potency...
5.
Ismail I, Martensson S, Moshinsky D, Rice A, Tang C, Howlett A, et al.
Oncogene
. 2003 Dec;
23(4):873-82.
PMID: 14661061
Loss of the DNA-dependent protein kinase (DNA-PK) results in increased sensitivity to ionizing radiation due to inefficient repair of DNA double-strand breaks. Overexpression of DNA-PK in tumor cells conversely results...
6.
Patel N, Sun L, Moshinsky D, Chen H, Leahy K, Le P, et al.
J Pharmacol Exp Ther
. 2003 May;
306(3):838-45.
PMID: 12766257
Vascular endothelial growth factor (VEGF) is a key driver of the neovascularization and vascular permeability that leads to the loss of visual acuity in diabetic retinopathy and neovascular age-related macular...
7.
Li X, Huang P, Cui J, Zhang J, Tang C
Bioorg Med Chem Lett
. 2003 May;
13(11):1939-42.
PMID: 12749903
Cyclin-dependent kinases (CDKs) are essential in the control of cell cycle progression. Inhibition of CDKs represents a new approach for pharmacological intervention in the treatment of a variety of proliferative...
8.
Huang P, Ramphal J, Wei J, Liang C, Jallal B, McMahon G, et al.
Bioorg Med Chem
. 2003 Mar;
11(8):1835-49.
PMID: 12659770
Protein tyrosine phosphatases (PTPs) are important in the regulation of signal transduction processes. Certain enzymes of this class are considered as potential therapeutic targets in the treatment of a variety...
9.
Sun L, Liang C, Shirazian S, Zhou Y, Miller T, Cui J, et al.
J Med Chem
. 2003 Mar;
46(7):1116-9.
PMID: 12646019
To improve the antitumor properties and optimize the pharmaceutical properties including solubility and protein binding of indolin-2-ones, a number of different basic and weakly basic analogues were designed and synthesized....
10.
Mendel D, Laird A, Xin X, Louie S, Christensen J, Li G, et al.
Clin Cancer Res
. 2003 Jan;
9(1):327-37.
PMID: 12538485
One challenging aspect in the clinical development of molecularly targeted therapies, which represent a new and promising approach to treating cancers, has been the identification of a biologically active dose...