Chitvan Mittal
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Explore the profile of Chitvan Mittal including associated specialties, affiliations and a list of published articles.
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11
Citations
229
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Recent Articles
1.
van Breugel M, van Kruijsbergen I, Mittal C, Lieftink C, Brouwer I, van den Brand T, et al.
Mol Cell
. 2023 Nov;
83(23):4205-4221.e9.
PMID: 37995691
Transcription of tRNA genes by RNA polymerase III (RNAPIII) is tuned by signaling cascades. The emerging notion of differential tRNA gene regulation implies the existence of additional regulatory mechanisms. However,...
2.
Mittal C, Lang O, Lai W, Pugh B
Genes Dev
. 2022 Oct;
36(17-18):985-1001.
PMID: 36302553
Genome-wide, little is understood about how proteins organize at inducible promoters before and after induction and to what extent inducible and constitutive architectures depend on cofactors. We report that sequence-specific...
3.
Sams K, Mukai C, Marks B, Mittal C, Demeter E, Nelissen S, et al.
Reprod Biol Endocrinol
. 2022 Oct;
20(1):150.
PMID: 36224627
Background: Peptidylarginine deiminase enzymes (PADs) convert arginine residues to citrulline in a process called citrullination or deimination. Recently, two PADs, PAD2 and PAD4, have been linked to hormone signaling in...
4.
Rossi M, Kuntala P, Lai W, Yamada N, Badjatia N, Mittal C, et al.
Nature
. 2021 Mar;
592(7853):309-314.
PMID: 33692541
The genome-wide architecture of chromatin-associated proteins that maintains chromosome integrity and gene regulation is not well defined. Here we use chromatin immunoprecipitation, exonuclease digestion and DNA sequencing (ChIP-exo/seq) to define...
5.
Badjatia N, Rossi M, Bataille A, Mittal C, Lai W, Pugh B
Cell Rep
. 2021 Jan;
34(3):108640.
PMID: 33472084
In multicellular eukaryotes, RNA polymerase (Pol) II pauses transcription ~30-50 bp after initiation. While the budding yeast Saccharomyces has its transcription mechanisms mostly conserved with other eukaryotes, it appears to...
6.
Gallego L, Schneider M, Mittal C, Romanauska A, Gudino Carrillo R, Schubert T, et al.
Nature
. 2020 Mar;
579(7800):592-597.
PMID: 32214243
The conserved yeast E3 ubiquitin ligase Bre1 and its partner, the E2 ubiquitin-conjugating enzyme Rad6, monoubiquitinate histone H2B across gene bodies during the transcription cycle. Although processive ubiquitination might-in principle-arise...
7.
Mittal C, Culbertson S, Shogren-Knaak M
J Biol Chem
. 2018 Jul;
293(35):13736-13749.
PMID: 30054274
The Spt-Ada-Gcn5 acetyltransferase (SAGA) family of transcriptional coactivators are prototypical nucleosome acetyltransferase complexes that regulate multiple steps in gene transcription. The size and complexity of both the SAGA enzyme and...
8.
Vinayachandran V, Reja R, Rossi M, Park B, Rieber L, Mittal C, et al.
Genome Res
. 2018 Feb;
28(3):357-366.
PMID: 29444801
Gene expression is controlled by a variety of proteins that interact with the genome. Their precise organization and mechanism of action at every promoter remains to be worked out. To...
9.
Young I, Mittal C, Shogren-Knaak M
Protein Expr Purif
. 2015 Oct;
118:92-7.
PMID: 26481273
Lysine acetylation is a common post-translational modification, which is especially prevalent in histone proteins in chromatin. A number of strategies exist for generating histone proteins containing lysine acetylation, but an...
10.
Mittal C, Blacketer M, Shogren-Knaak M
Anal Biochem
. 2014 Apr;
457:51-8.
PMID: 24769374
The establishment of posttranslational chromatin modifications is a major mechanism for regulating how genomic DNA is utilized. However, current in vitro chromatin assays do not monitor histone modifications at individual...